Environmental light and endogenous antioxidants as the main determinants of non-cancer ocular diseases

Sergio C. Saccà, Anna Maria Roszkowska, Alberto Izzotti

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The human eye is constantly exposed to sunlight and artificial lighting. Exogenous sources of reactive oxygen species (ROS) such as UV light, visible light, ionizing radiation, chemotherapeutics, and environmental toxins contribute to oxidative damage in ocular tissues. Long-term exposure to these insults places the aging eye at considerable risk for pathological consequences of oxidative stress. Furthermore, in eye tissues, mitochondria are an important endogenous source of ROS. Over time, all ocular structures, from the tear film to the retina, undergo oxidative stress, and therefore, the antioxidant defenses of each tissue assume the role of a safeguard against degenerative ocular pathologies. The ocular surface and cornea protect the other ocular tissues and are significantly exposed to oxidative stress of environmental origin. Overwhelming of antioxidant defenses in these tissues clinically manifests as pathologies including pterygium, corneal dystrophies, and endothelial Fuch's dystrophy. The crystalline lens is highly susceptible to oxidative damage in aging because its cells and their intracellular proteins are not turned over or replaced, thus providing the basis for cataractogenesis. The trabecular meshwork, which is the anterior chamber tissue devoted to aqueous humor drainage, has a particular susceptibility to mitochondrial oxidative injury that affects its endothelium and leads to an intraocular pressure increase that marks the beginning of glaucoma. Photo-oxidative stress can cause acute or chronic retinal damage. The pathogenesis of age-related macular degeneration involves oxidative stress and death of the retinal pigment epithelium followed by death of the overlying photoreceptors. Accordingly, converging evidence indicates that mutagenic mechanisms of environmental and endogenous sources play a fundamental pathogenic role in degenerative eye diseases.

Original languageEnglish
Pages (from-to)153-171
Number of pages19
JournalMutation Research - Reviews in Mutation Research
Volume752
Issue number2
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Eye Diseases
Antioxidants
Light
Oxidative Stress
Reactive Oxygen Species
Fuchs' Endothelial Dystrophy
Pathology
Trabecular Meshwork
Pterygium
Crystalline Lens
Retinal Pigment Epithelium
Aqueous Humor
Sunlight
Macular Degeneration
Anterior Chamber
Ultraviolet Rays
Ionizing Radiation
Lighting
Tears
Intraocular Pressure

Keywords

  • Antioxidant
  • Eye
  • Oxidative damage
  • UV radiations

ASJC Scopus subject areas

  • Genetics
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

Environmental light and endogenous antioxidants as the main determinants of non-cancer ocular diseases. / Saccà, Sergio C.; Roszkowska, Anna Maria; Izzotti, Alberto.

In: Mutation Research - Reviews in Mutation Research, Vol. 752, No. 2, 04.2013, p. 153-171.

Research output: Contribution to journalArticle

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