Environmental risk factors for REM sleep behavior disorder

A multicenter case-control study

R. B. Postuma, J. Y. Montplaisir, A. Pelletier, Y. Dauvilliers, W. Oertel, A. Iranzo, L. Ferini-Strambi, I. Arnulf, B. Hogl, R. Manni, T. Miyamoto, G. Mayer, K. Stiasny-Kolster, M. Puligheddu, Y. Ju, P. Jennum, K. Sonka, J. Santamaria, M. L. Fantini, M. Zucconi & 7 others S. Leu-Semenescu, B. Frauscher, M. Terzaghi, M. Miyamoto, M. M. Unger, V. Cochen De Cock, C. Wolfson

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Objective: Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and is commonly a prediagnostic sign of parkinsonism and dementia. Since risk factors have not been defined, we initiated a multicenter case-control study to assess environmental and lifestyle risk factors for REM sleep behavior disorder. Methods: Cases were patients with idiopathic REM sleep behavior disorder who were free of dementia and parkinsonism, recruited from 13 International REM Sleep Behavior Disorder Study Group centers. Controls were matched according to age and sex. Potential environmental and lifestyle risk factors were assessed via standardized questionnaire. Unconditional logistic regression adjusting for age, sex, and center was conducted to investigate the environmental factors. Results: A total of 694 participants (347 patients, 347 controls) were recruited. Among cases, mean age was 67.7 ± 9.6 years and 81.0% were male. Cases were more likely to smoke (ever smokers = 64.0% vs 55.5%, adjusted odds ratio [OR] = 1.43, p = 0.028). Caffeine and alcohol use were not different between cases and controls. Cases were more likely to report previous head injury (19.3% vs 12.7%, OR=1.59, p=0.037). Cases had fewer years of formal schooling (11.1 ± 4.4 years vs 12.7 ± 4.3, p <0.001), and were more likely to report having worked Abstract: farmers (19.7% vs 12.5% OR = 1.67, p = 0.022) with borderline increase in welding (17.8% vs 12.1%, OR = 1.53, p = 0.063). Previous occupational pesticide exposure was more prevalent in cases than controls (11.8% vs 6.1%, OR = 2.16, p = 0.008). Conclusions: Smoking, head injury, pesticide exposure, and farming are potential risk factors for idiopathic REM sleep behavior disorder.

Original languageEnglish
Pages (from-to)428-434
Number of pages7
JournalNeurology
Volume79
Issue number5
DOIs
Publication statusPublished - Jul 31 2012

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REM Sleep Behavior Disorder
Case-Control Studies
Odds Ratio
Parkinsonian Disorders
Craniocerebral Trauma
Pesticides
Dementia
Life Style
Parasomnias
Welding
Occupational Exposure
Caffeine
Agriculture
Smoke
Logistic Models
Smoking
Alcohols
Sleep
Risk Factors
Environmental Risk

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Postuma, R. B., Montplaisir, J. Y., Pelletier, A., Dauvilliers, Y., Oertel, W., Iranzo, A., ... Wolfson, C. (2012). Environmental risk factors for REM sleep behavior disorder: A multicenter case-control study. Neurology, 79(5), 428-434. https://doi.org/10.1212/WNL.0b013e31825dd383

Environmental risk factors for REM sleep behavior disorder : A multicenter case-control study. / Postuma, R. B.; Montplaisir, J. Y.; Pelletier, A.; Dauvilliers, Y.; Oertel, W.; Iranzo, A.; Ferini-Strambi, L.; Arnulf, I.; Hogl, B.; Manni, R.; Miyamoto, T.; Mayer, G.; Stiasny-Kolster, K.; Puligheddu, M.; Ju, Y.; Jennum, P.; Sonka, K.; Santamaria, J.; Fantini, M. L.; Zucconi, M.; Leu-Semenescu, S.; Frauscher, B.; Terzaghi, M.; Miyamoto, M.; Unger, M. M.; De Cock, V. Cochen; Wolfson, C.

In: Neurology, Vol. 79, No. 5, 31.07.2012, p. 428-434.

Research output: Contribution to journalArticle

Postuma, RB, Montplaisir, JY, Pelletier, A, Dauvilliers, Y, Oertel, W, Iranzo, A, Ferini-Strambi, L, Arnulf, I, Hogl, B, Manni, R, Miyamoto, T, Mayer, G, Stiasny-Kolster, K, Puligheddu, M, Ju, Y, Jennum, P, Sonka, K, Santamaria, J, Fantini, ML, Zucconi, M, Leu-Semenescu, S, Frauscher, B, Terzaghi, M, Miyamoto, M, Unger, MM, De Cock, VC & Wolfson, C 2012, 'Environmental risk factors for REM sleep behavior disorder: A multicenter case-control study', Neurology, vol. 79, no. 5, pp. 428-434. https://doi.org/10.1212/WNL.0b013e31825dd383
Postuma RB, Montplaisir JY, Pelletier A, Dauvilliers Y, Oertel W, Iranzo A et al. Environmental risk factors for REM sleep behavior disorder: A multicenter case-control study. Neurology. 2012 Jul 31;79(5):428-434. https://doi.org/10.1212/WNL.0b013e31825dd383
Postuma, R. B. ; Montplaisir, J. Y. ; Pelletier, A. ; Dauvilliers, Y. ; Oertel, W. ; Iranzo, A. ; Ferini-Strambi, L. ; Arnulf, I. ; Hogl, B. ; Manni, R. ; Miyamoto, T. ; Mayer, G. ; Stiasny-Kolster, K. ; Puligheddu, M. ; Ju, Y. ; Jennum, P. ; Sonka, K. ; Santamaria, J. ; Fantini, M. L. ; Zucconi, M. ; Leu-Semenescu, S. ; Frauscher, B. ; Terzaghi, M. ; Miyamoto, M. ; Unger, M. M. ; De Cock, V. Cochen ; Wolfson, C. / Environmental risk factors for REM sleep behavior disorder : A multicenter case-control study. In: Neurology. 2012 ; Vol. 79, No. 5. pp. 428-434.
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abstract = "Objective: Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and is commonly a prediagnostic sign of parkinsonism and dementia. Since risk factors have not been defined, we initiated a multicenter case-control study to assess environmental and lifestyle risk factors for REM sleep behavior disorder. Methods: Cases were patients with idiopathic REM sleep behavior disorder who were free of dementia and parkinsonism, recruited from 13 International REM Sleep Behavior Disorder Study Group centers. Controls were matched according to age and sex. Potential environmental and lifestyle risk factors were assessed via standardized questionnaire. Unconditional logistic regression adjusting for age, sex, and center was conducted to investigate the environmental factors. Results: A total of 694 participants (347 patients, 347 controls) were recruited. Among cases, mean age was 67.7 ± 9.6 years and 81.0{\%} were male. Cases were more likely to smoke (ever smokers = 64.0{\%} vs 55.5{\%}, adjusted odds ratio [OR] = 1.43, p = 0.028). Caffeine and alcohol use were not different between cases and controls. Cases were more likely to report previous head injury (19.3{\%} vs 12.7{\%}, OR=1.59, p=0.037). Cases had fewer years of formal schooling (11.1 ± 4.4 years vs 12.7 ± 4.3, p <0.001), and were more likely to report having worked Abstract: farmers (19.7{\%} vs 12.5{\%} OR = 1.67, p = 0.022) with borderline increase in welding (17.8{\%} vs 12.1{\%}, OR = 1.53, p = 0.063). Previous occupational pesticide exposure was more prevalent in cases than controls (11.8{\%} vs 6.1{\%}, OR = 2.16, p = 0.008). Conclusions: Smoking, head injury, pesticide exposure, and farming are potential risk factors for idiopathic REM sleep behavior disorder.",
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T1 - Environmental risk factors for REM sleep behavior disorder

T2 - A multicenter case-control study

AU - Postuma, R. B.

AU - Montplaisir, J. Y.

AU - Pelletier, A.

AU - Dauvilliers, Y.

AU - Oertel, W.

AU - Iranzo, A.

AU - Ferini-Strambi, L.

AU - Arnulf, I.

AU - Hogl, B.

AU - Manni, R.

AU - Miyamoto, T.

AU - Mayer, G.

AU - Stiasny-Kolster, K.

AU - Puligheddu, M.

AU - Ju, Y.

AU - Jennum, P.

AU - Sonka, K.

AU - Santamaria, J.

AU - Fantini, M. L.

AU - Zucconi, M.

AU - Leu-Semenescu, S.

AU - Frauscher, B.

AU - Terzaghi, M.

AU - Miyamoto, M.

AU - Unger, M. M.

AU - De Cock, V. Cochen

AU - Wolfson, C.

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N2 - Objective: Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and is commonly a prediagnostic sign of parkinsonism and dementia. Since risk factors have not been defined, we initiated a multicenter case-control study to assess environmental and lifestyle risk factors for REM sleep behavior disorder. Methods: Cases were patients with idiopathic REM sleep behavior disorder who were free of dementia and parkinsonism, recruited from 13 International REM Sleep Behavior Disorder Study Group centers. Controls were matched according to age and sex. Potential environmental and lifestyle risk factors were assessed via standardized questionnaire. Unconditional logistic regression adjusting for age, sex, and center was conducted to investigate the environmental factors. Results: A total of 694 participants (347 patients, 347 controls) were recruited. Among cases, mean age was 67.7 ± 9.6 years and 81.0% were male. Cases were more likely to smoke (ever smokers = 64.0% vs 55.5%, adjusted odds ratio [OR] = 1.43, p = 0.028). Caffeine and alcohol use were not different between cases and controls. Cases were more likely to report previous head injury (19.3% vs 12.7%, OR=1.59, p=0.037). Cases had fewer years of formal schooling (11.1 ± 4.4 years vs 12.7 ± 4.3, p <0.001), and were more likely to report having worked Abstract: farmers (19.7% vs 12.5% OR = 1.67, p = 0.022) with borderline increase in welding (17.8% vs 12.1%, OR = 1.53, p = 0.063). Previous occupational pesticide exposure was more prevalent in cases than controls (11.8% vs 6.1%, OR = 2.16, p = 0.008). Conclusions: Smoking, head injury, pesticide exposure, and farming are potential risk factors for idiopathic REM sleep behavior disorder.

AB - Objective: Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and is commonly a prediagnostic sign of parkinsonism and dementia. Since risk factors have not been defined, we initiated a multicenter case-control study to assess environmental and lifestyle risk factors for REM sleep behavior disorder. Methods: Cases were patients with idiopathic REM sleep behavior disorder who were free of dementia and parkinsonism, recruited from 13 International REM Sleep Behavior Disorder Study Group centers. Controls were matched according to age and sex. Potential environmental and lifestyle risk factors were assessed via standardized questionnaire. Unconditional logistic regression adjusting for age, sex, and center was conducted to investigate the environmental factors. Results: A total of 694 participants (347 patients, 347 controls) were recruited. Among cases, mean age was 67.7 ± 9.6 years and 81.0% were male. Cases were more likely to smoke (ever smokers = 64.0% vs 55.5%, adjusted odds ratio [OR] = 1.43, p = 0.028). Caffeine and alcohol use were not different between cases and controls. Cases were more likely to report previous head injury (19.3% vs 12.7%, OR=1.59, p=0.037). Cases had fewer years of formal schooling (11.1 ± 4.4 years vs 12.7 ± 4.3, p <0.001), and were more likely to report having worked Abstract: farmers (19.7% vs 12.5% OR = 1.67, p = 0.022) with borderline increase in welding (17.8% vs 12.1%, OR = 1.53, p = 0.063). Previous occupational pesticide exposure was more prevalent in cases than controls (11.8% vs 6.1%, OR = 2.16, p = 0.008). Conclusions: Smoking, head injury, pesticide exposure, and farming are potential risk factors for idiopathic REM sleep behavior disorder.

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