Enzyme polymorphisms influencing the metabolism of heterocyclic aromatic amines

Luisa Airoldi, Cinzia Magagnotti, Roberta Pastorelli, Roberto Fanelli

Research output: Contribution to journalArticlepeer-review

Abstract

Heterocyclic aromatic amines are dietary carcinogens possibly involved in human carcinogenesis, DNA-adduct formation being an obligatory step in this multistage process. Heterocyclic amine binding to DNA largely depends on the balance between metabolic activation and detoxification pathways and DNA repair efficiency. Several genes coding for metabolic enzymes are polymorphic, which affects gene expression and/or enzyme activity. This paper briefly reviews the effect of polymorphisms of activating/detoxifying enzymes on the metabolism of heterocyclic amines. Despite some epidemiological evidence of an association between genetic polymorphisms and susceptibility to cancer possibly resulting from dietary exposure to heterocyclic aromatic amines (HA), the genetic polymorphisms had only slight effects on biomarker levels, suggesting the existence of further unknown factors.

Original languageEnglish
Pages (from-to)175-181
Number of pages7
JournalJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume802
Issue number1
DOIs
Publication statusPublished - Mar 25 2004

Keywords

  • Enzyme polymorphisms
  • Heterocyclic aromatic amines metabolism

ASJC Scopus subject areas

  • Biochemistry

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