Enzyme replacement therapy in adult-onset glycogenosis II: Is quantitative muscle MRI helpful?

A. Pichiecchio; G. U. Poloni; S. Ravaglia; M. Ponzio; G. Germani; D. Maranzana; A. Costa; A. Repetto; E. Tavazzi; C. Danesino; A. Moglia; S. Bastianello

doi:10.1002/mus.21304

Enzyme replacement therapy in adult-onset glycogenosis II: Is quantitative muscle MRI helpful?

A. Pichiecchio, G. U. Poloni, S. Ravaglia, M. Ponzio, G. Germani, D. Maranzana, A. Costa, A. Repetto, E. Tavazzi, C. Danesino, A. Moglia, S. Bastianello

Research output: Contribution to journal › Article › peer-review

Abstract

Although it has been shown that muscle magnetic resonance imaging (MRI) improves the phenotypic characterization of patients with neuromuscular disorders and allows accurate quantification of muscle and adipose tissue distribution, to date quantitative MRI has not been used to assess the therapeutic response in clinical trials of neuromuscular diseases. We discuss quantitative MRI findings after a 6-month course of enzyme replacement therapy administered to nine patients with adult-onset glycogenosis II.

Original language	English
Pages (from-to)	122-125
Number of pages	4
Journal	Muscle and Nerve
Volume	40
Issue number	1
DOIs	https://doi.org/10.1002/mus.21304
Publication status	Published - Jul 2009

Keywords

Acid maltase deficiency
Enzyme-replacement therapy
ERT
Glycogenosis II
Muscle MRI
Pompe disease

ASJC Scopus subject areas

Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)
Physiology

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abstract = "Although it has been shown that muscle magnetic resonance imaging (MRI) improves the phenotypic characterization of patients with neuromuscular disorders and allows accurate quantification of muscle and adipose tissue distribution, to date quantitative MRI has not been used to assess the therapeutic response in clinical trials of neuromuscular diseases. We discuss quantitative MRI findings after a 6-month course of enzyme replacement therapy administered to nine patients with adult-onset glycogenosis II.",

keywords = "Acid maltase deficiency, Enzyme-replacement therapy, ERT, Glycogenosis II, Muscle MRI, Pompe disease",

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T2 - Is quantitative muscle MRI helpful?

AU - Pichiecchio, A.

AU - Poloni, G. U.

AU - Ravaglia, S.

AU - Ponzio, M.

AU - Germani, G.

AU - Maranzana, D.

AU - Costa, A.

AU - Repetto, A.

AU - Tavazzi, E.

AU - Danesino, C.

AU - Moglia, A.

AU - Bastianello, S.

PY - 2009/7

Y1 - 2009/7

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AB - Although it has been shown that muscle magnetic resonance imaging (MRI) improves the phenotypic characterization of patients with neuromuscular disorders and allows accurate quantification of muscle and adipose tissue distribution, to date quantitative MRI has not been used to assess the therapeutic response in clinical trials of neuromuscular diseases. We discuss quantitative MRI findings after a 6-month course of enzyme replacement therapy administered to nine patients with adult-onset glycogenosis II.

KW - Acid maltase deficiency

KW - Enzyme-replacement therapy

KW - ERT

KW - Glycogenosis II

KW - Muscle MRI

KW - Pompe disease

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Enzyme replacement therapy in adult-onset glycogenosis II: Is quantitative muscle MRI helpful?

Abstract

Keywords

ASJC Scopus subject areas

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