Enzyme replacement therapy in adult-onset glycogenosis II: Is quantitative muscle MRI helpful?

A. Pichiecchio, G. U. Poloni, S. Ravaglia, M. Ponzio, G. Germani, D. Maranzana, A. Costa, A. Repetto, E. Tavazzi, C. Danesino, A. Moglia, S. Bastianello

Research output: Contribution to journalArticle

Abstract

Although it has been shown that muscle magnetic resonance imaging (MRI) improves the phenotypic characterization of patients with neuromuscular disorders and allows accurate quantification of muscle and adipose tissue distribution, to date quantitative MRI has not been used to assess the therapeutic response in clinical trials of neuromuscular diseases. We discuss quantitative MRI findings after a 6-month course of enzyme replacement therapy administered to nine patients with adult-onset glycogenosis II.

Original languageEnglish
Pages (from-to)122-125
Number of pages4
JournalMuscle and Nerve
Volume40
Issue number1
DOIs
Publication statusPublished - Jul 2009

Keywords

  • Acid maltase deficiency
  • Enzyme-replacement therapy
  • ERT
  • Glycogenosis II
  • Muscle MRI
  • Pompe disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology

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