Enzymes of lysosomal origin in the cerebrospinal fluid and plasma of patients with multiple sclerosis

G. Goi; D. Caputo; C. Bairati; A. Lombardo; A. B. Burlina; P. Ferrante; C. L. Cazzullo; G. Tettamanti

doi:10.1159/000116888

Enzymes of lysosomal origin in the cerebrospinal fluid and plasma of patients with multiple sclerosis

G. Goi, D. Caputo, C. Bairati, A. Lombardo, A. B. Burlina, P. Ferrante, C. L. Cazzullo, G. Tettamanti

Research output: Contribution to journal › Article › peer-review

Abstract

Several lysosomal enzymes were determined in 47 and 62 samples of CSF and plasma, respectively, obtained from MS patients. CSF levels of most enzymes considered were significantly lower in patients when compared to those of the controls, whereas the plasma levels vary little and appeared to be influenced by the course of the disease. The most interesting result is the one concerning the P-Z)-glucuronidase in the plasma: in relapsing-remitting patients in the still untreated acute phase, the levels remain noticeably diminished in comparison to controls. The data suggest the potential of using this enzyme to monitor the progression of the disease.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	European Neurology
Volume	33
Issue number	1
DOIs	https://doi.org/10.1159/000116888
Publication status	Published - 1993

Keywords

Cerebrospinal fluid
Lysosomal enzymes
Multiple sclerosis
Plasma

ASJC Scopus subject areas

Clinical Neurology
Neurology

Access to Document

10.1159/000116888

Fingerprint Dive into the research topics of 'Enzymes of lysosomal origin in the cerebrospinal fluid and plasma of patients with multiple sclerosis'. Together they form a unique fingerprint.

Cite this

@article{1a8160b2481e436aa42bd5337f235dad,

title = "Enzymes of lysosomal origin in the cerebrospinal fluid and plasma of patients with multiple sclerosis",

abstract = "Several lysosomal enzymes were determined in 47 and 62 samples of CSF and plasma, respectively, obtained from MS patients. CSF levels of most enzymes considered were significantly lower in patients when compared to those of the controls, whereas the plasma levels vary little and appeared to be influenced by the course of the disease. The most interesting result is the one concerning the P-Z)-glucuronidase in the plasma: in relapsing-remitting patients in the still untreated acute phase, the levels remain noticeably diminished in comparison to controls. The data suggest the potential of using this enzyme to monitor the progression of the disease.",

keywords = "Cerebrospinal fluid, Lysosomal enzymes, Multiple sclerosis, Plasma",

author = "G. Goi and D. Caputo and C. Bairati and A. Lombardo and Burlina, {A. B.} and P. Ferrante and Cazzullo, {C. L.} and G. Tettamanti",

year = "1993",

doi = "10.1159/000116888",

language = "English",

volume = "33",

pages = "1--4",

journal = "European Neurology",

issn = "0014-3022",

publisher = "S. Karger AG",

number = "1",

}

TY - JOUR

T1 - Enzymes of lysosomal origin in the cerebrospinal fluid and plasma of patients with multiple sclerosis

AU - Goi, G.

AU - Caputo, D.

AU - Bairati, C.

AU - Lombardo, A.

AU - Burlina, A. B.

AU - Ferrante, P.

AU - Cazzullo, C. L.

AU - Tettamanti, G.

PY - 1993

Y1 - 1993

N2 - Several lysosomal enzymes were determined in 47 and 62 samples of CSF and plasma, respectively, obtained from MS patients. CSF levels of most enzymes considered were significantly lower in patients when compared to those of the controls, whereas the plasma levels vary little and appeared to be influenced by the course of the disease. The most interesting result is the one concerning the P-Z)-glucuronidase in the plasma: in relapsing-remitting patients in the still untreated acute phase, the levels remain noticeably diminished in comparison to controls. The data suggest the potential of using this enzyme to monitor the progression of the disease.

AB - Several lysosomal enzymes were determined in 47 and 62 samples of CSF and plasma, respectively, obtained from MS patients. CSF levels of most enzymes considered were significantly lower in patients when compared to those of the controls, whereas the plasma levels vary little and appeared to be influenced by the course of the disease. The most interesting result is the one concerning the P-Z)-glucuronidase in the plasma: in relapsing-remitting patients in the still untreated acute phase, the levels remain noticeably diminished in comparison to controls. The data suggest the potential of using this enzyme to monitor the progression of the disease.

KW - Cerebrospinal fluid

KW - Lysosomal enzymes

KW - Multiple sclerosis

KW - Plasma

UR - http://www.scopus.com/inward/record.url?scp=0027460253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027460253&partnerID=8YFLogxK

U2 - 10.1159/000116888

DO - 10.1159/000116888

M3 - Article

C2 - 8440277

AN - SCOPUS:0027460253

VL - 33

SP - 1

EP - 4

JO - European Neurology

JF - European Neurology

SN - 0014-3022

IS - 1

ER -

Enzymes of lysosomal origin in the cerebrospinal fluid and plasma of patients with multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this