We evaluated Eosinophil Cationic Protein (ECP), Protein X (EPX), Myeloperoxidase (MPO) and total IgE serum levels on cord blood, at five days (only ECP and IgE) and at six months of life in two groups of infants with (group A) or without positive parental history for atopy (group B). The two groups of infants were further divided in five subgroups, depending on the method of feeding: 18 breast-fed at risk for atopy infants (group A 1); 10 formula-fed at risk for atopy infants (group A2); 10 partially hydrolysed whey formulafed at risk for atopy infants (group A3); 15 breast-fed control infants (group B1); 10 formulated control infants (group B2). The statistical analysis showed a significant difference (p = 0,03) of ECP cord serum levels between the A and B groups, a significant increase of ECP serum levels at five days in group B infants, a significant increase of ECP and EPX serum levels at six months in group A and B infants. No differences were observed of MPO serum levels. The results in the five subgroups showed a significant increase of ECP serum levels at six months in group A1 (p = 0,01), A2 (p = 0,05), B1 (p = 0,0001) and B2 (p = 0,05) infants, a signifcant difference of IgE serum levels at six months of the A1 (p = 0,0009) and A3 (p = 0,02) as compared to the A2 group, an increase of IgE serum levels at six months in group B2 (p = 0,068) as compared to B1 infants. In conclusion we observed that only ECP, of the factors evaluated, can give some information on the atopic status at birth of at risk for atopy infants, and that a partially hydrolysed whey formula seems to have a reduced stimulatory activity on the synthesis of ECP and IgE. The protective value of breast feeding is once again confirmed by the lower IgE serum levels at six months of life.
|Translated title of the contribution||Eosinophil Cationic Protein (ECP), Protein X (EPX), Myeloperoxidase (MPO) and total IgE serum levels during the first six months of life|
|Number of pages||4|
|Journal||Rivista Italiana di Pediatria|
|Issue number||3 SUPPL.|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health