Eosinophilic airway inflammation is increased in children with asthma and food allergies

Neeta Kulkarni, Vincenzo Ragazzo, Silvia Costella, Giorgio Piacentini, Attilio Boner, Christopher O'Callaghan, Alessandro Fiocchi, Ahmad Kantar

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Asthma is associated with food allergies in a significant number of children, with evidence linking allergies to asthma severity and morbidity. In this study, we tested our hypothesis that the eosinophilic lower airway inflammation is higher in asthmatic children with food allergies. Aims: The aims of the study were to compare the eosinophilic inflammatory markers in asthmatic children with and without food allergies. Materials and Methods: Children with asthma, with (n=22) and (n=53) without food allergies were included. All subjects were classified according to the GINA guidelines (2009) and had received at least 3months of anti-inflammatory therapy prior to testing. Fractional exhaled nitric oxide and sputum differential counts were performed using standard techniques. Results: Children with asthma and food allergies had significantly higher fractional exhaled nitric oxide median (range) [(22.4 (6.1-86.9) vs. 10.3 (2.7-38.7) (p=0.01)] and sputum eosinophil percentage [15.5 (5.0-53.0) vs. 2.0 (0-20) (p

Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalPediatric Allergy and Immunology
Volume23
Issue number1
DOIs
Publication statusPublished - Feb 2012

Keywords

  • Asthma
  • Eosinophils
  • Food hypersensitivity
  • Nitric oxide
  • Sputum

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health
  • Immunology

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