Eosinophilic esophagitis in children: current knowledge to open new horizons

Tommaso Alterio, Sabrina Cardile, Claire Trayers, Simona Valenti, Italia Loddo, Roxana Mardare, Antonella Mosca, Valerio Nobili

Research output: Contribution to journalArticle

Abstract

Eosinophilic Esophagitis (EoE) is a chronic immune/antigen-mediated condition which is also driven by genetic and environmental factors. It has been deeply investigated over the last years and its incidence is widely increasing in childhood. Although atopic diseases are closely linked with EoE, it does not recognize a classical IgE-mediate immune pathogenesis but it is rather a T helper type 2 inflammatory process. Familial clustering supports genetic predisposition in EoE and recent advances in understanding the genetic basis for EoE may eventually translate into targeted management of the disease. EoE diagnosis is based on clinical symptoms, micro, and macroscopic findings along with exclusion of gastroesophageal reflux disease (GERD) evidence. Management of the disease encompasses both dietary and pharmacological solutions that need to be specifically targeted on patients' history, clinical symptoms, and diagnostic evaluations. New therapies, currently not available in children, may represent the basis for future therapeutic options in the next years.

Original languageEnglish
Pages (from-to)822-829
Number of pages8
JournalScandinavian Journal of Gastroenterology
Volume54
Issue number7
DOIs
Publication statusPublished - Jul 2019

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