Eosinophilic esophagitis: latest insights from diagnosis to therapy

Alain Schoepfer, Carine Blanchard, Heather Dawson, Alfredo Lucendo, Aurelio Mauro, Camillo Ribi, Ekaterina Safroneeva, Edoardo V. Savarino, Roberto Penagini

Research output: Contribution to journalReview articlepeer-review

Abstract

Eosinophilic esophagitis (EoE) represents a chronic, local immune-mediated esophageal disease, characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation. Other systemic and local causes of esophageal eosinophilia should be excluded. Clinical manifestations or pathologic data should not be interpreted in isolation. EoE was first described as a distinct disease entity in 1993. Most patients are diagnosed with underlying food allergies. The first diagnostic and therapeutic guidelines were published in 2007 with a first update in 2011. In 2017, new international guidelines were published based on the GRADE methodology. These guidelines provide, among many other topics, insights on the role of proton pump inhibitor-responsive esophageal eosinophilia. Over the last two decades, considerable progress was made by stakeholders regarding the understanding of EoE's pathogenesis, genetic background, natural history, allergy workup, standardization of assessment of disease activity, evaluation of minimally invasive diagnostic tools, and new therapeutic approaches. This brief review provides further insights into latest diagnostic and therapeutic advances.

Original languageEnglish
Pages (from-to)84-93
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume1434
Issue number1
DOIs
Publication statusPublished - Dec 1 2018

Keywords

  • dysphagia
  • eosinophilic esophagitis
  • food allergy
  • guidelines
  • patient-reported outcomes
  • proton pump inhibitor-responsive esophageal eosinophilia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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