TY - JOUR
T1 - Eosinophilic globules in bronchoalveolar lavage fluid of patients with systemic sclerosis-related interstitial lung disease
T2 - A diagnostically useful, previously unreported finding in a retrospective and prospective study, including differential diagnosis with other idiopathic and secondary interstitial lung diseases
AU - Rossi, Giulio
AU - Andreani, Alessandro
AU - Morandi, Paola
AU - Marchioni, Alessandro
AU - Corradini, Paolo
AU - Cappiello, Gaia
AU - Bortolotti, Monica
AU - Qosja, Ardian
AU - Manzini, Carlo
AU - Ferri, Clodoveo
AU - Richeldi, Luca
AU - Cavazza, Alberto
PY - 2008/12
Y1 - 2008/12
N2 - Bronchoalveolar lavage (BAL) is a minimally invasive method possibly representing a diagnostic tool in the evaluation of interstitial lung diseases (ILDs) of different causes. We first describe herein the morphologic, histochemical, and immunohistochemical features of previously unreported eosinophilic globular deposits of acellular amorphous material of uncertain nature in a relatively large series of 227 BAL samples obtained from patients with various ILDs. Overall, eosinophilic globules were detected in 18 cases (7.9%), 16 of which were in patients with systemic sclerosis (SSc)-related ILD (16/50 [32%]) and in 2 cases of apparently idiopathic usual interstitial pneumonia. Apart from the possible diagnostic information of this finding, in patients with SSc, the globules were significantly related to BAL neutrophilia or eosinophilia and extensive ILD in high-resolution computed tomography (P <.0001). Differential diagnosis with other types of acellular globular materials observed in BAL samples is also discussed.
AB - Bronchoalveolar lavage (BAL) is a minimally invasive method possibly representing a diagnostic tool in the evaluation of interstitial lung diseases (ILDs) of different causes. We first describe herein the morphologic, histochemical, and immunohistochemical features of previously unreported eosinophilic globular deposits of acellular amorphous material of uncertain nature in a relatively large series of 227 BAL samples obtained from patients with various ILDs. Overall, eosinophilic globules were detected in 18 cases (7.9%), 16 of which were in patients with systemic sclerosis (SSc)-related ILD (16/50 [32%]) and in 2 cases of apparently idiopathic usual interstitial pneumonia. Apart from the possible diagnostic information of this finding, in patients with SSc, the globules were significantly related to BAL neutrophilia or eosinophilia and extensive ILD in high-resolution computed tomography (P <.0001). Differential diagnosis with other types of acellular globular materials observed in BAL samples is also discussed.
KW - Bronchoalveolar lavage
KW - Collagen
KW - Interstitial pneumonia
KW - Periodic acid-Schiff
KW - Systemic sclerosis
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U2 - 10.1309/AJCPJ6W9XOFEXIYS
DO - 10.1309/AJCPJ6W9XOFEXIYS
M3 - Article
C2 - 19019770
AN - SCOPUS:58049208374
VL - 130
SP - 927
EP - 933
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 6
ER -