Eosinophilic inflammation in stable chronic obstructive pulmonary disease

Relationship with neutrophils and airway function

Giovanni Balzano, Francesco Stefanelli, Carmela Iorio, Alberto De Felice, Enrico M. Melillo, Michele Martucci, Gaetano Melillo

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

The number and significance of airway eosinophils in stable COPD is controversial. Aims of this study were to evaluate airway inflammation in patients with stable COPD compared with other groups, and to examine the correlations between inflammatory markers and functional indices of airway obstruction. Cellular analysis and evaluation of eosinophil cationic protein (ECP) levels in induced sputum were made in 46 subjects (10 patients with clinically stable COPD, 15 patients with asthma, 11 asymptomatic smokers, and 10 healthy control subjects). As expected, eosinophils were significantly (p <0.01) higher in patients with asthma (22.2%) than in other groups (COPD, 0.7%; smokers, 0.2%; control subjects, 0.2%), and neutrophils were significantly (p <0.01) higher in patients with COPD (77.5%) than in the other groups (asthma, 26.7%; smokers, 33.1%; control subjects, 35.9%). However, eosinophils were also increased in patients with COPD, as compared with healthy controls (p <0.05). Sputum ECP levels were significantly and similarly higher in both asthma and COPD groups than in the other two groups (p <0.01). In patients with COPD and asymptomatic smokers, considered as a whole, good correlations were found between eosinophils and ECP, on the one hand, and between FEV1 and the FEV1/FVC ratio, on the other. Our data suggest that eosinophils may be involved in the airway inflammation of COPD.

Original languageEnglish
Pages (from-to)1486-1492
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume160
Issue number5 I
Publication statusPublished - 1999

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Chronic Obstructive Pulmonary Disease
Neutrophils
Inflammation
Eosinophils
Eosinophil Cationic Protein
Asthma
Sputum
Airway Obstruction
Healthy Volunteers

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Eosinophilic inflammation in stable chronic obstructive pulmonary disease : Relationship with neutrophils and airway function. / Balzano, Giovanni; Stefanelli, Francesco; Iorio, Carmela; De Felice, Alberto; Melillo, Enrico M.; Martucci, Michele; Melillo, Gaetano.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 160, No. 5 I, 1999, p. 1486-1492.

Research output: Contribution to journalArticle

Balzano, Giovanni ; Stefanelli, Francesco ; Iorio, Carmela ; De Felice, Alberto ; Melillo, Enrico M. ; Martucci, Michele ; Melillo, Gaetano. / Eosinophilic inflammation in stable chronic obstructive pulmonary disease : Relationship with neutrophils and airway function. In: American Journal of Respiratory and Critical Care Medicine. 1999 ; Vol. 160, No. 5 I. pp. 1486-1492.
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