A case of eosinophilic pustular folliculitis (Ofuji's disease) in a 31-year-old HIV-1 seronegative tunisian man is described. Lesions consisted of erythematous papulopustules, nodules and plaques distributed on the face, involving the skin area innervated by the right mandibular nerve. Histological examination revealed a dense infiltrate of mononuclear cells, neutrophils and numerous eosinophils surrounding and infiltrating hair follicules and sebaceous glands, associated with focal or diffuse destruction of follicular structures. Bacterial and fungal cultures from cutaneous lesions were negative. The eruption disappeared after a 15 day trial with trimethoprim-sulfamethoxazole (25 mg/kg/die), leaving a brown hyperpigmentation. Eosinophilic pustular folliculitis is a rare skin disorder which is being increasingly reported in HIV-positive patients, especially in those with low peripheral blood CD4+ T cells and at increasing risk of developing opportunistic infections. It is characterized by recurrent sterile papules, pustules, and plaques distributed on the face, trunk and arms. The lack of knowledge about the etiology and pathogenesis of the disease is reflected by the absence of effective treatments.
|Translated title of the contribution||Eosinophilic pustular folliculitis|
|Number of pages||5|
|Publication status||Published - 1993|
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