Eosinophils and gastric cancerogenesis: Evidence of a relationship in humans

M. Melato, R. Caruso, F. Sasso, S. Bucconi, C. Inferrera

Research output: Contribution to journalArticlepeer-review


Aim. To investigate the presence of eosinophils in the gastric wall of the normal stomach, stomach of atopic patients, and in the gastric stump of patients operated on for benign causes. Also, various preneoplastic conditions (hyperplastic or adenomatous polyps and peptic ulcer) and two neoplastic conditions were considered. Method. Samples of gastric tissue were obtained by biopsy in different clinical conditions. The mean number of eosinophils was determined by counting in 10 high power fields. Results. A significantly higher number of eosinophils was found in all preneoplastic and neoplastic conditions studied. Conclusion. Since eosinophilic infiltration was not in correlation to the presence of necrosis and/or granulation tissue, eosinophils may be considered a useful marker of preneoplastic and neoplastic changes in the stomach.

Original languageEnglish
Pages (from-to)27-29
Number of pages3
JournalCroatian Medical Journal
Issue number1
Publication statusPublished - 1995


  • Eosinophils
  • Gastrectomy
  • Neoplasm immunology
  • Stomach neoplasm prognosis
  • Stomach ulcer

ASJC Scopus subject areas

  • Medicine(all)


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