Abstract
| Original language | English |
|---|---|
| Article number | 9095275 |
| Journal | BioMed Research International |
| Volume | 2018 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2018 |
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Eosinophils from Physiology to Disease: A Comprehensive Review. / Ramirez, GA; Yacoub, MR; Ripa, M; Mannina, Daniele; Cariddi, A; Saporiti, N; Ciceri, F; Castagna, A; Colombo, G; Dagna, L.
In: BioMed Research International, Vol. 2018, No. 5, 9095275, 2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Eosinophils from Physiology to Disease: A Comprehensive Review
AU - Ramirez, GA
AU - Yacoub, MR
AU - Ripa, M
AU - Mannina, Daniele
AU - Cariddi, A
AU - Saporiti, N
AU - Ciceri, F
AU - Castagna, A
AU - Colombo, G
AU - Dagna, L
PY - 2018
Y1 - 2018
N2 - Despite being the second least represented granulocyte subpopulation in the circulating blood, eosinophils are receiving a growing interest from the scientific community, due to their complex pathophysiological role in a broad range of local and systemic inflammatory diseases as well as in cancer and thrombosis. Eosinophils are crucial for the control of parasitic infections, but increasing evidence suggests that they are also involved in vital defensive tasks against bacterial and viral pathogens including HIV. On the other side of the coin, eosinophil potential to provide a strong defensive response against invading microbes through the release of a large array of compounds can prove toxic to the host tissues and dysregulate haemostasis. Increasing knowledge of eosinophil biological behaviour is leading to major changes in established paradigms for the classification and diagnosis of several allergic and autoimmune diseases and has paved the way to a "golden age" of eosinophil-targeted agents. In this review, we provide a comprehensive update on the pathophysiological role of eosinophils in host defence, inflammation, and cancer and discuss potential clinical implications in light of recent therapeutic advances. © 2018 Giuseppe A. Ramirez et al.
AB - Despite being the second least represented granulocyte subpopulation in the circulating blood, eosinophils are receiving a growing interest from the scientific community, due to their complex pathophysiological role in a broad range of local and systemic inflammatory diseases as well as in cancer and thrombosis. Eosinophils are crucial for the control of parasitic infections, but increasing evidence suggests that they are also involved in vital defensive tasks against bacterial and viral pathogens including HIV. On the other side of the coin, eosinophil potential to provide a strong defensive response against invading microbes through the release of a large array of compounds can prove toxic to the host tissues and dysregulate haemostasis. Increasing knowledge of eosinophil biological behaviour is leading to major changes in established paradigms for the classification and diagnosis of several allergic and autoimmune diseases and has paved the way to a "golden age" of eosinophil-targeted agents. In this review, we provide a comprehensive update on the pathophysiological role of eosinophils in host defence, inflammation, and cancer and discuss potential clinical implications in light of recent therapeutic advances. © 2018 Giuseppe A. Ramirez et al.
U2 - 10.1155/2018/9095275
DO - 10.1155/2018/9095275
M3 - Article
VL - 2018
JO - BioMed Research International
JF - BioMed Research International
SN - 2314-6133
IS - 5
M1 - 9095275
ER -