Epidemic HIV-related Kaposi's sarcoma: A retrospective analysis and validation of TIS staging

G. Tambussi, L. Repetto, V. Torri, A. Saracco, L. Moresco, A. Antinori, R. Zerboni, A. Lazzarin, F. Badellino

Research output: Contribution to journalArticlepeer-review

Abstract

Background: We wished to assess the clinical value in terms of treatment choice and establishment of the prognosis of the ACTG classification modified (TNM-TIS) according to the recent guidelines of CDC for the classification of the HIV infection in patients with HIV-related epidemic Kaposi's sarcoma (EKS). Patients: We retrospectively studied 296 HIV-positive individuals with EKS. Patients were initially classified according to the NW system and then reclassified according to the TNM-TIS proposal which considers three major parameters: T, anatomical extent of the lesion; I, immune system status; S, HIV-related systemic illness. Methods: Survival analyses according to patient characteristics and the different TNM-TIS classification stages were performed; curves were compared using the Kaplan-Meyer method, and predictive factors for survival using the Cox model. Results: Of the parameters considered in the TNM-TIS staging system, the T variable was not predictive of survival. Conversely, I and S variables revealed predictive value in the survival analyses, when considered separately and together. Conclusions: The extent of cutaneous or mucosal lesions of Kaposi's sarcoma did not correlate with prognosis. However, both CD4+ cell count and history of systemic illness were predictive of survival. Indicators of HIV infection must be included in the clinical evaluation of EKS patients and taken into account when choosing optimal treatment.

Original languageEnglish
Pages (from-to)383-387
Number of pages5
JournalAnnals of Oncology
Volume6
Issue number4
Publication statusPublished - 1995

Keywords

  • Epidemic Kaposi's sarcoma
  • HIV
  • Staging
  • Survival
  • TIS

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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