Epidemic multidrug-resistant Acinetobacter baumannii related to European clonal types I and II in Rome (Italy)

S. D'Arezzo, A. Capone, N. Petrosillo, P. Visca, M. Ballardini, S. Bartolini, E. Bordi, A. Di Stefano, M. Galiè, R. Minniti, M. Meledandri, L. Pacciani, G. Parisi, G. Prignano, C. Santini, M. Valmarin, M. Venditti, S. Ziantoni

Research output: Contribution to journalArticle

Abstract

The molecular epidemiology and the genetic basis of antibiotic resistance in 88 multidrug-resistant (MDR) Acinetobacter baumannii strains isolated during 18months from infected patients in seven intensive care units (ICUs) in Rome were investigated. Random amplified polymorphic DNA and macrorestriction analysis identified two predominant clonal types, genetically related to the European epidemic clones I (type 2) and II (type 1), accounting for 98.9% of A..baumannii ICU isolates. Type 1 was isolated from all ICUs under survey. Class 1 integrons of 2.2 and 2.5 kb were detected in type 1 and type 2 isolates, respectively. The integron structures were similar to those previously determined for epidemic A. baumannii strains from various European countries, and suggestive of integron rearrangement/exchange among isolates related to the European epidemic clones I and II. Carbapenem resistance was associated with the presence of the bla OXA-58 gene in type 1 isolates. The results indicate that the A. baumannii type 1 clone has a high potential of spreading among hospitals.

Original languageEnglish
Pages (from-to)347-357
Number of pages11
JournalClinical Microbiology and Infection
Volume15
Issue number4
DOIs
Publication statusPublished - 2009

Keywords

  • Acinetobacter baumannii
  • Epidemiology
  • Integrons
  • Multidrug resistance
  • Nosocomial infection
  • Typing

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    D'Arezzo, S., Capone, A., Petrosillo, N., Visca, P., Ballardini, M., Bartolini, S., Bordi, E., Di Stefano, A., Galiè, M., Minniti, R., Meledandri, M., Pacciani, L., Parisi, G., Prignano, G., Santini, C., Valmarin, M., Venditti, M., & Ziantoni, S. (2009). Epidemic multidrug-resistant Acinetobacter baumannii related to European clonal types I and II in Rome (Italy). Clinical Microbiology and Infection, 15(4), 347-357. https://doi.org/10.1111/j.1469-0691.2009.02668.x