Epidemiologic variables and outcome of 1972 young patients with acute myocardial infarction: Data from the GISSI-2 database

Tiziano Moccetti, Roberto Malacrida, Elena Pasotti, Fabrizio Sessa, Michele Genoni, Simona Barlera, Fabio Turazza, Aldo P. Maggioni

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Background: Acute myocardial infarction in younger patients is uncommon, occurring mainly in men. The recent introduction of thrombolysis improved survival, left ventricular function, and infarct size. Objective: To evaluate characteristics and clinical outcome of the patients younger than 50 years randomized in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico study. All patients received a thrombolytic treatment. Methods: The 11483 patients were divided into 3 age subgroups: younger than 50 years (17.2%), between 50 and 70 years (60.2%), and older than 70 years (22.6%). All relations between variables were first determined by an unadjusted analysis. An adjusted analysis was performed by multiple logistic regression models for in-hospital and 6-month mortality. Results: While older patients had a significantly higher rate of a history of hypercholesterolemia, diabetes, and hypertension, smoking and a positive family history were significantly more frequent in younger patients. Total in-hospital and 6-month mortality were significantly lower in patients younger than 50 years (2.7% and 1.2%, respectively) than in patients between 50 and 70 years old (6.9% and 2.7%) and those older than 70 years (21.1% and 8.4%). After multivariate analysis, the predictive value of age was confirmed. Conclusions: Our findings, based on a large group of patients who received thrombolytic treatment, suggest that younger age is a significant independent indicator of a favorable prognosis after acute myocardial infarction.

Original languageEnglish
Pages (from-to)865-869
Number of pages5
JournalArchives of Internal Medicine
Volume157
Issue number8
Publication statusPublished - Apr 28 1997

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Myocardial Infarction
Databases
Logistic Models
Mortality
Hypercholesterolemia
Left Ventricular Function
Multivariate Analysis
Smoking
Hypertension
Survival
Therapeutics

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Moccetti, T., Malacrida, R., Pasotti, E., Sessa, F., Genoni, M., Barlera, S., ... Maggioni, A. P. (1997). Epidemiologic variables and outcome of 1972 young patients with acute myocardial infarction: Data from the GISSI-2 database. Archives of Internal Medicine, 157(8), 865-869.

Epidemiologic variables and outcome of 1972 young patients with acute myocardial infarction : Data from the GISSI-2 database. / Moccetti, Tiziano; Malacrida, Roberto; Pasotti, Elena; Sessa, Fabrizio; Genoni, Michele; Barlera, Simona; Turazza, Fabio; Maggioni, Aldo P.

In: Archives of Internal Medicine, Vol. 157, No. 8, 28.04.1997, p. 865-869.

Research output: Contribution to journalArticle

Moccetti, T, Malacrida, R, Pasotti, E, Sessa, F, Genoni, M, Barlera, S, Turazza, F & Maggioni, AP 1997, 'Epidemiologic variables and outcome of 1972 young patients with acute myocardial infarction: Data from the GISSI-2 database', Archives of Internal Medicine, vol. 157, no. 8, pp. 865-869.
Moccetti T, Malacrida R, Pasotti E, Sessa F, Genoni M, Barlera S et al. Epidemiologic variables and outcome of 1972 young patients with acute myocardial infarction: Data from the GISSI-2 database. Archives of Internal Medicine. 1997 Apr 28;157(8):865-869.
Moccetti, Tiziano ; Malacrida, Roberto ; Pasotti, Elena ; Sessa, Fabrizio ; Genoni, Michele ; Barlera, Simona ; Turazza, Fabio ; Maggioni, Aldo P. / Epidemiologic variables and outcome of 1972 young patients with acute myocardial infarction : Data from the GISSI-2 database. In: Archives of Internal Medicine. 1997 ; Vol. 157, No. 8. pp. 865-869.
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AB - Background: Acute myocardial infarction in younger patients is uncommon, occurring mainly in men. The recent introduction of thrombolysis improved survival, left ventricular function, and infarct size. Objective: To evaluate characteristics and clinical outcome of the patients younger than 50 years randomized in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico study. All patients received a thrombolytic treatment. Methods: The 11483 patients were divided into 3 age subgroups: younger than 50 years (17.2%), between 50 and 70 years (60.2%), and older than 70 years (22.6%). All relations between variables were first determined by an unadjusted analysis. An adjusted analysis was performed by multiple logistic regression models for in-hospital and 6-month mortality. Results: While older patients had a significantly higher rate of a history of hypercholesterolemia, diabetes, and hypertension, smoking and a positive family history were significantly more frequent in younger patients. Total in-hospital and 6-month mortality were significantly lower in patients younger than 50 years (2.7% and 1.2%, respectively) than in patients between 50 and 70 years old (6.9% and 2.7%) and those older than 70 years (21.1% and 8.4%). After multivariate analysis, the predictive value of age was confirmed. Conclusions: Our findings, based on a large group of patients who received thrombolytic treatment, suggest that younger age is a significant independent indicator of a favorable prognosis after acute myocardial infarction.

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