TY - JOUR
T1 - Epidemiological and clinical features of pregnant women with HIV
T2 - A 21-year perspective from a highly specialized regional center in southern Italy
AU - Martinelli, Pasquale
AU - Agangi, Annalisa
AU - Sansone, Matilde
AU - Maruotti, Giuseppe Maria
AU - Wilma, Buffolano
AU - Paladini, Dario
AU - Pizzuti, Renato
AU - Floridia, Marco
PY - 2008/1
Y1 - 2008/1
N2 - Purpose: To analyze the changes over two decades in HIV-infected pregnant women followed at a highly specialized regional center for antenatal care in southern Italy. Method: Since 1985, all HIV-infected pregnant women attending our center have been monitored using progressively updated protocols. Results: By December 2006, 230 deliveries in 159 women had been monitored. Deliveries in HIV-infected women increased from 0.16% (4/2,499) of all deliveries in 1985 to 0.73% (15/2,042) in 2006. The sociodemographic profile of the women changed greatly over the study period, and there was a shift from injecting drug use to heterosexual contact as the main transmission route and an increased proportion of foreign women. Subsequent to improvements in clinical care, the proportion of infected pregnant women receiving antiretroviral treatment increased from 27% (17/63) before 1996 to 81% (63/78) in 2006, with a corresponding decrease in the mother-to-child transmission rate from 36% (16/44) to 0.6% (1/157). Conclusion: The increasing number of HIV-infected pregnant women can be attributed to nonselective antenatal HIV screening, the spread of HIV infection through heterosexual contacts, and the desire of HIV-infected women to have children. In this context, highly specialized reference centers can play an important role in providing HIV-infected pregnant women with optimal care and in reducing mother-to-child transmission rates to very low levels.
AB - Purpose: To analyze the changes over two decades in HIV-infected pregnant women followed at a highly specialized regional center for antenatal care in southern Italy. Method: Since 1985, all HIV-infected pregnant women attending our center have been monitored using progressively updated protocols. Results: By December 2006, 230 deliveries in 159 women had been monitored. Deliveries in HIV-infected women increased from 0.16% (4/2,499) of all deliveries in 1985 to 0.73% (15/2,042) in 2006. The sociodemographic profile of the women changed greatly over the study period, and there was a shift from injecting drug use to heterosexual contact as the main transmission route and an increased proportion of foreign women. Subsequent to improvements in clinical care, the proportion of infected pregnant women receiving antiretroviral treatment increased from 27% (17/63) before 1996 to 81% (63/78) in 2006, with a corresponding decrease in the mother-to-child transmission rate from 36% (16/44) to 0.6% (1/157). Conclusion: The increasing number of HIV-infected pregnant women can be attributed to nonselective antenatal HIV screening, the spread of HIV infection through heterosexual contacts, and the desire of HIV-infected women to have children. In this context, highly specialized reference centers can play an important role in providing HIV-infected pregnant women with optimal care and in reducing mother-to-child transmission rates to very low levels.
KW - AIDS
KW - Epidemiology
KW - HIV
KW - Italy
KW - Pregnancy
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U2 - 10.1310/hct0901-36
DO - 10.1310/hct0901-36
M3 - Article
C2 - 18215980
AN - SCOPUS:38949156817
VL - 9
SP - 36
EP - 42
JO - HIV Clinical Trials
JF - HIV Clinical Trials
SN - 1528-4336
IS - 1
ER -