Epidemiological and molecular assessment of a measles outbreak in a highly vaccinated population of northeast Italy

P. D'Agaro, G. Dal Molin, T. Gallo, T. Rossi, D. Santon, M. Busetti, M. Comar, C. Campello

Research output: Contribution to journalArticle

Abstract

Two distinct measles outbreaks, unrelated from the epidemiological point of view but caused by genetically related strains, occurred in the Friuli Venezia Giulia region of northeastern Italy. Forty-two cases were reported during the period April - May 2008. In the first outbreak the index case was a teacher who introduced the virus into the Pordenone area, involving eight adolescents and young adults. The other concomitant outbreak occurred in the city of Trieste with 33 cases. The containment of the epidemics can be explained by the high MMR vaccine coverage in an area where the first dose was delivered to 93·4% and the second dose to 88·3% of the target children. Phylogenetic analysis of 14 measles virus strains showed that they belonged to a unique D4 genotype indistinguishable from the MVs/Enfield.GBR/14.07 strain, probably introduced from areas (i.e. Piedmont and Germany) where this genotype was present or had recently caused a large epidemic.

Original languageEnglish
Pages (from-to)1727-1733
Number of pages7
JournalEpidemiology and Infection
Volume139
Issue number11
DOIs
Publication statusPublished - Nov 2011

Fingerprint

Measles
Italy
Disease Outbreaks
Genotype
Measles-Mumps-Rubella Vaccine
Population
Measles virus
Germany
Young Adult
Viruses

Keywords

  • Community outbreaks
  • epidemiology
  • measles
  • molecular epidemiology
  • vaccine-preventable diseases

ASJC Scopus subject areas

  • Infectious Diseases
  • Epidemiology

Cite this

D'Agaro, P., Molin, G. D., Gallo, T., Rossi, T., Santon, D., Busetti, M., ... Campello, C. (2011). Epidemiological and molecular assessment of a measles outbreak in a highly vaccinated population of northeast Italy. Epidemiology and Infection, 139(11), 1727-1733. https://doi.org/10.1017/S095026881100032X

Epidemiological and molecular assessment of a measles outbreak in a highly vaccinated population of northeast Italy. / D'Agaro, P.; Molin, G. Dal; Gallo, T.; Rossi, T.; Santon, D.; Busetti, M.; Comar, M.; Campello, C.

In: Epidemiology and Infection, Vol. 139, No. 11, 11.2011, p. 1727-1733.

Research output: Contribution to journalArticle

D'Agaro, P. ; Molin, G. Dal ; Gallo, T. ; Rossi, T. ; Santon, D. ; Busetti, M. ; Comar, M. ; Campello, C. / Epidemiological and molecular assessment of a measles outbreak in a highly vaccinated population of northeast Italy. In: Epidemiology and Infection. 2011 ; Vol. 139, No. 11. pp. 1727-1733.
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