Epidemiological aspects of transmitted HIV drug resistance

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Transmitted human immunodeficiency virus (HIV) resistance to antiretrovirals (i.e. resistance in antiretroviral naive patients) emerged during the 1990s as a potentially relevant public health problem. HIV variants resistant to all classes of approved antiretroviral agents have been identified in significant proportions antiretroviral naive patients, and this phenomenon appears as a potential threat to the effectiveness of highly active antiretroviral therapy. Available data from surveys conducted between 1996 and 2001 show the prevalence of drug resistance among newly HIV-infected individuals to range from 3% to above 20% in North America, and from 5% to 15% in Europe. Increases in prevalence observed during the late 1990s in some studies are not confirmed by most recent data. Transmission of multidrug resistance still appears to be an uncommon occurrence. However, methodological heterogeneity and problems in study design make it difficult to compare results between different surveys and to draw firm conclusions from the results. There is a clear need to improve surveillance systems aimed at identifying patients at the time of primary infection and to standardize laboratory methods for the identification of genetic markers of resistance to be used for epidemiological purposes.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalScandinavian Journal of Infectious Diseases, Supplement
Issue number106
Publication statusPublished - Dec 2003

Fingerprint

Drug Resistance
HIV
Anti-Retroviral Agents
Highly Active Antiretroviral Therapy
Multiple Drug Resistance
North America
Genetic Markers
Public Health
Infection
Surveys and Questionnaires

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology
  • Immunology and Microbiology(all)
  • Infectious Diseases

Cite this

Epidemiological aspects of transmitted HIV drug resistance. / Girardi, Enrico.

In: Scandinavian Journal of Infectious Diseases, Supplement, No. 106, 12.2003, p. 17-20.

Research output: Contribution to journalArticle

@article{bfefc0c85eba479cb001c28fe3ad9ebe,
title = "Epidemiological aspects of transmitted HIV drug resistance",
abstract = "Transmitted human immunodeficiency virus (HIV) resistance to antiretrovirals (i.e. resistance in antiretroviral naive patients) emerged during the 1990s as a potentially relevant public health problem. HIV variants resistant to all classes of approved antiretroviral agents have been identified in significant proportions antiretroviral naive patients, and this phenomenon appears as a potential threat to the effectiveness of highly active antiretroviral therapy. Available data from surveys conducted between 1996 and 2001 show the prevalence of drug resistance among newly HIV-infected individuals to range from 3{\%} to above 20{\%} in North America, and from 5{\%} to 15{\%} in Europe. Increases in prevalence observed during the late 1990s in some studies are not confirmed by most recent data. Transmission of multidrug resistance still appears to be an uncommon occurrence. However, methodological heterogeneity and problems in study design make it difficult to compare results between different surveys and to draw firm conclusions from the results. There is a clear need to improve surveillance systems aimed at identifying patients at the time of primary infection and to standardize laboratory methods for the identification of genetic markers of resistance to be used for epidemiological purposes.",
author = "Enrico Girardi",
year = "2003",
month = "12",
language = "English",
pages = "17--20",
journal = "Scandinavian Journal of Infectious Diseases, Supplement",
issn = "0300-8878",
publisher = "Taylor and Francis Ltd.",
number = "106",

}

TY - JOUR

T1 - Epidemiological aspects of transmitted HIV drug resistance

AU - Girardi, Enrico

PY - 2003/12

Y1 - 2003/12

N2 - Transmitted human immunodeficiency virus (HIV) resistance to antiretrovirals (i.e. resistance in antiretroviral naive patients) emerged during the 1990s as a potentially relevant public health problem. HIV variants resistant to all classes of approved antiretroviral agents have been identified in significant proportions antiretroviral naive patients, and this phenomenon appears as a potential threat to the effectiveness of highly active antiretroviral therapy. Available data from surveys conducted between 1996 and 2001 show the prevalence of drug resistance among newly HIV-infected individuals to range from 3% to above 20% in North America, and from 5% to 15% in Europe. Increases in prevalence observed during the late 1990s in some studies are not confirmed by most recent data. Transmission of multidrug resistance still appears to be an uncommon occurrence. However, methodological heterogeneity and problems in study design make it difficult to compare results between different surveys and to draw firm conclusions from the results. There is a clear need to improve surveillance systems aimed at identifying patients at the time of primary infection and to standardize laboratory methods for the identification of genetic markers of resistance to be used for epidemiological purposes.

AB - Transmitted human immunodeficiency virus (HIV) resistance to antiretrovirals (i.e. resistance in antiretroviral naive patients) emerged during the 1990s as a potentially relevant public health problem. HIV variants resistant to all classes of approved antiretroviral agents have been identified in significant proportions antiretroviral naive patients, and this phenomenon appears as a potential threat to the effectiveness of highly active antiretroviral therapy. Available data from surveys conducted between 1996 and 2001 show the prevalence of drug resistance among newly HIV-infected individuals to range from 3% to above 20% in North America, and from 5% to 15% in Europe. Increases in prevalence observed during the late 1990s in some studies are not confirmed by most recent data. Transmission of multidrug resistance still appears to be an uncommon occurrence. However, methodological heterogeneity and problems in study design make it difficult to compare results between different surveys and to draw firm conclusions from the results. There is a clear need to improve surveillance systems aimed at identifying patients at the time of primary infection and to standardize laboratory methods for the identification of genetic markers of resistance to be used for epidemiological purposes.

UR - http://www.scopus.com/inward/record.url?scp=1242343608&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1242343608&partnerID=8YFLogxK

M3 - Article

C2 - 15000576

AN - SCOPUS:1242343608

SP - 17

EP - 20

JO - Scandinavian Journal of Infectious Diseases, Supplement

JF - Scandinavian Journal of Infectious Diseases, Supplement

SN - 0300-8878

IS - 106

ER -