Epidemiological Evidence on the Relation between Coffee Intake and the Risk of Head and Neck Cancer

Alessandra Tavani, Carlotta Galeone, Federica Turati, Lodovica Cavalli, Carlo La Vecchia

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

About 30 epidemiological studies have investigated the role of coffee in the risk of head and neck cancers. A meta-analysis combined data published up to 2009 on such a relation, using a meta-analytic approach. For oral and pharyngeal cancer, the pooled relative risk (RR) was 0.64 (95% confidence interval (CI) 0.51-0.80) for the highest versus lowest coffee drinking, based on more than 2500 cases, with no significant heterogeneity across studies. The corresponding pooled RR for laryngeal cancer was 1.56 (95% CI 0.60-4.02). An update of the meta-analysis up to February 2013 confirmed a possible favorable role of high coffee consumption on oral and pharyngeal cancer, with a pooled RR of 0.72 (95% CI 0.59-0.87), based on about 7000 cases. A real favorable role of coffee in the etiology of oral and pharyngeal cancer is supported by dose-exposure relations and the consistency of results in different settings, populations, and strata of major covariates.

Original languageEnglish
Title of host publicationCoffee in Health and Disease Prevention
PublisherElsevier Inc.
Pages349-358
Number of pages10
ISBN (Print)9780124167162, 9780124095175
DOIs
Publication statusPublished - Nov 3 2014

Keywords

  • Coffee
  • Epidemiology
  • Head and neck cancer
  • Laryngeal cancer
  • Meta-analysis
  • Oral cancer
  • Pharyngeal cancer

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Tavani, A., Galeone, C., Turati, F., Cavalli, L., & La Vecchia, C. (2014). Epidemiological Evidence on the Relation between Coffee Intake and the Risk of Head and Neck Cancer. In Coffee in Health and Disease Prevention (pp. 349-358). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-409517-5.00038-3