TY - JOUR
T1 - Epidemiological features and disease-related concerns of a large cohort of Italian patients with active Crohn's disease
AU - Armuzzi, Alessandro
AU - Riegler, Gabriele
AU - Furfaro, Federica
AU - Baldoni, Monia
AU - Costa, Francesco
AU - Fortuna, Manuela
AU - Iaquinto, Gaetano
AU - Paese, Pietro
AU - Papi, Claudio
AU - Bossa, Fabrizio
AU - Tontini, Gian Eugenio
AU - Di Fino, Sara
AU - Gualberti, Giuliana
AU - Merolla, Rocco
AU - Rizzello, Fernando
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background-Aims: The SOLE study was conducted on a large cohort of Italian patients with moderate-severe Crohn's disease (CD) to assess epidemiological and disease characteristics and their correlation with disease-related worries, treatment satisfaction and adherence, workability. Methods: The following tools were used over 12 months to assess: • disease-related worries: Rating Form of Inflammatory Bowel Disease Patient Concerns, • impact on workability: Work Productivity and Activity Impairment-CD, • satisfaction: Treatment Satisfaction Questionnaire for Medication, • adherence: Medication Adherence Rating Scale. Results were correlated with demographic and clinical variables with linear regression models. Results: 552 patients with active CD (51% men) were recruited. Higher worries were having an ostomy bag and undergoing surgery. Variables associated with a higher RFIPC score included female sex, higher disease activity, lower treatment adherence (p < 0.001), previous surgical treatments (p = 0.003). 60% of patients claimed difficulties with activities of daily living. Lower VAS scores were reported by patients with disease duration >6years; treatment satisfaction/adherence was higher with anti-TNF-α treatment. Decreased hospitalizations during follow-up and improved workability/daily activities occurred with adalimumab, infliximab, azathioprine (p < 0.001). Conclusion: Worries included having an ostomy bag, undergoing surgery, developing cancer: conditions significantly associated with worsened disease activity and low treatment adherence. Higher treatment adherence scores/greater workability improvements were observed in patients treated with anti-TNF-α agents.
AB - Background-Aims: The SOLE study was conducted on a large cohort of Italian patients with moderate-severe Crohn's disease (CD) to assess epidemiological and disease characteristics and their correlation with disease-related worries, treatment satisfaction and adherence, workability. Methods: The following tools were used over 12 months to assess: • disease-related worries: Rating Form of Inflammatory Bowel Disease Patient Concerns, • impact on workability: Work Productivity and Activity Impairment-CD, • satisfaction: Treatment Satisfaction Questionnaire for Medication, • adherence: Medication Adherence Rating Scale. Results were correlated with demographic and clinical variables with linear regression models. Results: 552 patients with active CD (51% men) were recruited. Higher worries were having an ostomy bag and undergoing surgery. Variables associated with a higher RFIPC score included female sex, higher disease activity, lower treatment adherence (p < 0.001), previous surgical treatments (p = 0.003). 60% of patients claimed difficulties with activities of daily living. Lower VAS scores were reported by patients with disease duration >6years; treatment satisfaction/adherence was higher with anti-TNF-α treatment. Decreased hospitalizations during follow-up and improved workability/daily activities occurred with adalimumab, infliximab, azathioprine (p < 0.001). Conclusion: Worries included having an ostomy bag, undergoing surgery, developing cancer: conditions significantly associated with worsened disease activity and low treatment adherence. Higher treatment adherence scores/greater workability improvements were observed in patients treated with anti-TNF-α agents.
KW - Crohn's disease
KW - Patient's concerns
KW - Quality of life
KW - Treatment adherence and satisfaction
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U2 - 10.1016/j.dld.2018.12.019
DO - 10.1016/j.dld.2018.12.019
M3 - Article
AN - SCOPUS:85060338783
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
ER -