BACKGROUND-AIMS: The SOLE study was conducted on a large cohort of Italian patients with moderate-severe Crohn's disease (CD) to assess epidemiological and disease characteristics and their correlation with disease-related worries, treatment satisfaction and adherence, workability.
METHODS: The following tools were used over 12 months to assess: Results were correlated with demographic and clinical variables with linear regression models.
RESULTS: 552 patients with active CD (51% men) were recruited. Higher worries were having an ostomy bag and undergoing surgery. Variables associated with a higher RFIPC score included female sex, higher disease activity, lower treatment adherence (p < 0.001), previous surgical treatments (p = 0.003). 60% of patients claimed difficulties with activities of daily living. Lower VAS scores were reported by patients with disease duration >6years; treatment satisfaction/adherence was higher with anti-TNF-α treatment. Decreased hospitalizations during follow-up and improved workability/daily activities occurred with adalimumab, infliximab, azathioprine (p < 0.001).
CONCLUSION: Worries included having an ostomy bag, undergoing surgery, developing cancer: conditions significantly associated with worsened disease activity and low treatment adherence. Higher treatment adherence scores/greater workability improvements were observed in patients treated with anti-TNF-α agents.
- Activities of Daily Living
- Adaptation, Psychological
- Aged, 80 and over
- Crohn Disease/epidemiology
- Linear Models
- Middle Aged
- Patient Satisfaction/statistics & numerical data
- Prospective Studies
- Psychiatric Status Rating Scales
- Quality of Life
- Stress, Psychological/epidemiology
- Work Capacity Evaluation
- Young Adult