Epidemiological features and disease-related concerns of a large cohort of Italian patients with active Crohn's disease

Alessandro Armuzzi; Gabriele Riegler; Federica Furfaro; Monia Baldoni; Francesco Costa; Manuela Fortuna; Gaetano Iaquinto; Pietro Paese; Claudio Papi; Fabrizio Bossa; Gian Eugenio Tontini; Sara Di Fino; Giuliana Gualberti; Rocco Merolla; Fernando Rizzello

doi:10.1016/j.dld.2018.12.019

Epidemiological features and disease-related concerns of a large cohort of Italian patients with active Crohn's disease

Alessandro Armuzzi, Gabriele Riegler, Federica Furfaro, Monia Baldoni, Francesco Costa, Manuela Fortuna, Gaetano Iaquinto, Pietro Paese, Claudio Papi, Fabrizio Bossa, Gian Eugenio Tontini, Sara Di Fino, Giuliana Gualberti, Rocco Merolla, Fernando Rizzello

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND-AIMS: The SOLE study was conducted on a large cohort of Italian patients with moderate-severe Crohn's disease (CD) to assess epidemiological and disease characteristics and their correlation with disease-related worries, treatment satisfaction and adherence, workability.

METHODS: The following tools were used over 12 months to assess: Results were correlated with demographic and clinical variables with linear regression models.

RESULTS: 552 patients with active CD (51% men) were recruited. Higher worries were having an ostomy bag and undergoing surgery. Variables associated with a higher RFIPC score included female sex, higher disease activity, lower treatment adherence (p < 0.001), previous surgical treatments (p = 0.003). 60% of patients claimed difficulties with activities of daily living. Lower VAS scores were reported by patients with disease duration >6years; treatment satisfaction/adherence was higher with anti-TNF-α treatment. Decreased hospitalizations during follow-up and improved workability/daily activities occurred with adalimumab, infliximab, azathioprine (p < 0.001).

CONCLUSION: Worries included having an ostomy bag, undergoing surgery, developing cancer: conditions significantly associated with worsened disease activity and low treatment adherence. Higher treatment adherence scores/greater workability improvements were observed in patients treated with anti-TNF-α agents.

Original language	English
Pages (from-to)	804-811
Number of pages	8
Journal	Digestive and Liver Disease
Volume	51
Issue number	6
DOIs	https://doi.org/10.1016/j.dld.2018.12.019
Publication status	Published - Jun 2019

Keywords

Activities of Daily Living
Adaptation, Psychological
Adolescent
Adult
Aged
Aged, 80 and over
Crohn Disease/epidemiology
Female
Humans
Italy
Linear Models
Male
Middle Aged
Patient Satisfaction/statistics & numerical data
Prospective Studies
Psychiatric Status Rating Scales
Quality of Life
Stress, Psychological/epidemiology
Work Capacity Evaluation
Young Adult

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10.1016/j.dld.2018.12.019

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Armuzzi, A., Riegler, G., Furfaro, F., Baldoni, M., Costa, F., Fortuna, M., Iaquinto, G., Paese, P., Papi, C., Bossa, F., Tontini, G. E., Di Fino, S., Gualberti, G., Merolla, R., & Rizzello, F. (2019). Epidemiological features and disease-related concerns of a large cohort of Italian patients with active Crohn's disease. Digestive and Liver Disease, 51(6), 804-811. https://doi.org/10.1016/j.dld.2018.12.019

Armuzzi, A, Riegler, G, Furfaro, F, Baldoni, M, Costa, F, Fortuna, M, Iaquinto, G, Paese, P, Papi, C, Bossa, F , Tontini, GE, Di Fino, S, Gualberti, G, Merolla, R & Rizzello, F 2019, 'Epidemiological features and disease-related concerns of a large cohort of Italian patients with active Crohn's disease', Digestive and Liver Disease, vol. 51, no. 6, pp. 804-811. https://doi.org/10.1016/j.dld.2018.12.019

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title = "Epidemiological features and disease-related concerns of a large cohort of Italian patients with active Crohn's disease",

abstract = "BACKGROUND-AIMS: The SOLE study was conducted on a large cohort of Italian patients with moderate-severe Crohn's disease (CD) to assess epidemiological and disease characteristics and their correlation with disease-related worries, treatment satisfaction and adherence, workability.METHODS: The following tools were used over 12 months to assess: Results were correlated with demographic and clinical variables with linear regression models.RESULTS: 552 patients with active CD (51% men) were recruited. Higher worries were having an ostomy bag and undergoing surgery. Variables associated with a higher RFIPC score included female sex, higher disease activity, lower treatment adherence (p < 0.001), previous surgical treatments (p = 0.003). 60% of patients claimed difficulties with activities of daily living. Lower VAS scores were reported by patients with disease duration >6years; treatment satisfaction/adherence was higher with anti-TNF-α treatment. Decreased hospitalizations during follow-up and improved workability/daily activities occurred with adalimumab, infliximab, azathioprine (p < 0.001).CONCLUSION: Worries included having an ostomy bag, undergoing surgery, developing cancer: conditions significantly associated with worsened disease activity and low treatment adherence. Higher treatment adherence scores/greater workability improvements were observed in patients treated with anti-TNF-α agents.",

keywords = "Activities of Daily Living, Adaptation, Psychological, Adolescent, Adult, Aged, Aged, 80 and over, Crohn Disease/epidemiology, Female, Humans, Italy, Linear Models, Male, Middle Aged, Patient Satisfaction/statistics & numerical data, Prospective Studies, Psychiatric Status Rating Scales, Quality of Life, Stress, Psychological/epidemiology, Work Capacity Evaluation, Young Adult",

author = "Alessandro Armuzzi and Gabriele Riegler and Federica Furfaro and Monia Baldoni and Francesco Costa and Manuela Fortuna and Gaetano Iaquinto and Pietro Paese and Claudio Papi and Fabrizio Bossa and Tontini, {Gian Eugenio} and {Di Fino}, Sara and Giuliana Gualberti and Rocco Merolla and Fernando Rizzello",

year = "2019",

month = jun,

doi = "10.1016/j.dld.2018.12.019",

language = "English",

volume = "51",

pages = "804--811",

journal = "Digestive and Liver Disease",

issn = "1590-8658",

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number = "6",

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TY - JOUR

T1 - Epidemiological features and disease-related concerns of a large cohort of Italian patients with active Crohn's disease

AU - Armuzzi, Alessandro

AU - Riegler, Gabriele

AU - Furfaro, Federica

AU - Baldoni, Monia

AU - Costa, Francesco

AU - Fortuna, Manuela

AU - Iaquinto, Gaetano

AU - Paese, Pietro

AU - Papi, Claudio

AU - Bossa, Fabrizio

AU - Tontini, Gian Eugenio

AU - Di Fino, Sara

AU - Gualberti, Giuliana

AU - Merolla, Rocco

AU - Rizzello, Fernando

PY - 2019/6

Y1 - 2019/6

N2 - BACKGROUND-AIMS: The SOLE study was conducted on a large cohort of Italian patients with moderate-severe Crohn's disease (CD) to assess epidemiological and disease characteristics and their correlation with disease-related worries, treatment satisfaction and adherence, workability.METHODS: The following tools were used over 12 months to assess: Results were correlated with demographic and clinical variables with linear regression models.RESULTS: 552 patients with active CD (51% men) were recruited. Higher worries were having an ostomy bag and undergoing surgery. Variables associated with a higher RFIPC score included female sex, higher disease activity, lower treatment adherence (p < 0.001), previous surgical treatments (p = 0.003). 60% of patients claimed difficulties with activities of daily living. Lower VAS scores were reported by patients with disease duration >6years; treatment satisfaction/adherence was higher with anti-TNF-α treatment. Decreased hospitalizations during follow-up and improved workability/daily activities occurred with adalimumab, infliximab, azathioprine (p < 0.001).CONCLUSION: Worries included having an ostomy bag, undergoing surgery, developing cancer: conditions significantly associated with worsened disease activity and low treatment adherence. Higher treatment adherence scores/greater workability improvements were observed in patients treated with anti-TNF-α agents.

AB - BACKGROUND-AIMS: The SOLE study was conducted on a large cohort of Italian patients with moderate-severe Crohn's disease (CD) to assess epidemiological and disease characteristics and their correlation with disease-related worries, treatment satisfaction and adherence, workability.METHODS: The following tools were used over 12 months to assess: Results were correlated with demographic and clinical variables with linear regression models.RESULTS: 552 patients with active CD (51% men) were recruited. Higher worries were having an ostomy bag and undergoing surgery. Variables associated with a higher RFIPC score included female sex, higher disease activity, lower treatment adherence (p < 0.001), previous surgical treatments (p = 0.003). 60% of patients claimed difficulties with activities of daily living. Lower VAS scores were reported by patients with disease duration >6years; treatment satisfaction/adherence was higher with anti-TNF-α treatment. Decreased hospitalizations during follow-up and improved workability/daily activities occurred with adalimumab, infliximab, azathioprine (p < 0.001).CONCLUSION: Worries included having an ostomy bag, undergoing surgery, developing cancer: conditions significantly associated with worsened disease activity and low treatment adherence. Higher treatment adherence scores/greater workability improvements were observed in patients treated with anti-TNF-α agents.

KW - Activities of Daily Living

KW - Adaptation, Psychological

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Crohn Disease/epidemiology

KW - Female

KW - Humans

KW - Italy

KW - Linear Models

KW - Male

KW - Middle Aged

KW - Patient Satisfaction/statistics & numerical data

KW - Prospective Studies

KW - Psychiatric Status Rating Scales

KW - Quality of Life

KW - Stress, Psychological/epidemiology

KW - Work Capacity Evaluation

KW - Young Adult

U2 - 10.1016/j.dld.2018.12.019

DO - 10.1016/j.dld.2018.12.019

M3 - Article

C2 - 30685416

VL - 51

SP - 804

EP - 811

JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

SN - 1590-8658

IS - 6

ER -

Epidemiological features and disease-related concerns of a large cohort of Italian patients with active Crohn's disease

Abstract

Keywords

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