Epidemiological features and disease-related concerns of a large cohort of Italian patients with active Crohn's disease

Alessandro Armuzzi, Gabriele Riegler, Federica Furfaro, Monia Baldoni, Francesco Costa, Manuela Fortuna, Gaetano Iaquinto, Pietro Paese, Claudio Papi, Fabrizio Bossa, Gian Eugenio Tontini, Sara Di Fino, Giuliana Gualberti, Rocco Merolla, Fernando Rizzello

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BACKGROUND-AIMS: The SOLE study was conducted on a large cohort of Italian patients with moderate-severe Crohn's disease (CD) to assess epidemiological and disease characteristics and their correlation with disease-related worries, treatment satisfaction and adherence, workability.METHODS: The following tools were used over 12 months to assess: Results were correlated with demographic and clinical variables with linear regression models.RESULTS: 552 patients with active CD (51% men) were recruited. Higher worries were having an ostomy bag and undergoing surgery. Variables associated with a higher RFIPC score included female sex, higher disease activity, lower treatment adherence (p 6years; treatment satisfaction/adherence was higher with anti-TNF-α treatment. Decreased hospitalizations during follow-up and improved workability/daily activities occurred with adalimumab, infliximab, azathioprine (p 
Original languageEnglish
Pages (from-to)804-811
Number of pages8
JournalDigestive and Liver Disease
Issue number6
Publication statusPublished - Jun 2019


  • Activities of Daily Living
  • Adaptation, Psychological
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Crohn Disease/epidemiology
  • Female
  • Humans
  • Italy
  • Linear Models
  • Male
  • Middle Aged
  • Patient Satisfaction/statistics & numerical data
  • Prospective Studies
  • Psychiatric Status Rating Scales
  • Quality of Life
  • Stress, Psychological/epidemiology
  • Work Capacity Evaluation
  • Young Adult


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