Epidemiology and pathophysiology of LUTS/BPO

Alberto Briganti, Giorgio Gandaglia

Research output: Chapter in Book/Report/Conference proceedingChapter


The prevalence of benign prostatic hyperplasia (BPH) is strongly related to age, ranging from 8 % in men in their 50s to roughly 90 % in men older than 80 years. Although aging represents the strongest risk factor for this, chronic progressive disease, obesity, and metabolic syndrome have been recently shown to be associated with an increased risk of BPH. The etiology of BPH is still largely unsolved. However, tissue remodeling together with hormonal alterations and chronic inflammation have been recently proposed to be involved in its pathogenesis. The onset of symptoms is determined by prostatic enlargement, which consequently leads to bladder outlet obstruction and changes in the detrusor muscle function, finally resulting in LUTS.

Original languageEnglish
Title of host publicationMale LUTS/BPH Made Easy
PublisherSpringer-Verlag London Ltd
Number of pages11
ISBN (Print)9781447146889, 1447146875, 9781447146872
Publication statusPublished - Jan 1 2014


  • Benign prostatic hyperplasia
  • Epidemiology
  • Lower urinary tract symptoms
  • Pathophysiology
  • Risk factors

ASJC Scopus subject areas

  • Medicine(all)


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