Epidemiology and prognosis of candidaemia in elderly patients

Antonio Ramos-Martínez, Natalia Vicente-López, Isabel Sánchez-Romero, Belén Padilla, Paloma Merino-Amador, José Garnacho-Montero, Isabel Ruiz-Camps, Miguel Montejo, Miguel Salavert, José Mensa, Manuel Cuenca-Estrella, Members of the CANDIPOP Project from GEIH-GEMICOMED (SEIMC) and REIPI

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Abstract

The aim of the study was to analyse the epidemiology and prognosis of candidaemia in elderly patients. We performed a comparison of clinical presentation of candidaemia according to age and a study of hazard factors within a prospective programme performed in 29 hospitals. One hundred and seventy-six episodes occurred in elderly patients (>75 years), 227 episodes in middle-aged patients (61-75 years) and 232 episodes in younger patients (16-60 years). Central venous catheter, parenteral nutrition, neutropenia, immunosuppressive therapy and candidaemia caused by Candida parapsilosis were less frequent in elderly patients. These patients received inadequate antifungal therapy (57.3%) more frequently than middle-aged and younger patients (40.5% P < .001). Mortality during the first week (20%) and 30 days (42%) was higher in elderly patients. The variables independently associated with mortality in elderly patients during the first 7 days were acute renal failure (OR: 2.64), Pitt score (OR: 1.57) and appropriate antifungal therapy (OR: 0.132). Primary candidaemia (OR: 2.93), acute renal failure (OR: 3.68), Pitt score (OR: 1.38), appropriate antifungal therapy (OR: 0.3) and early removal of the central catheter (OR: 0.47) were independently associated with 30-day mortality.In conclussion, inadequate antifungal treatment is frequently prescribed to elderly patients with candidaemia and is related with early and late mortality.

Original languageEnglish
Pages (from-to)808-817
Number of pages10
JournalMycoses
Volume60
Issue number12
DOIs
Publication statusPublished - Dec 2017
Externally publishedYes

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Candidemia
Epidemiology
Mortality
Acute Kidney Injury
Therapeutics
Central Venous Catheters
Parenteral Nutrition
Immunosuppressive Agents
Neutropenia
Candida
Catheters

Keywords

  • Journal Article

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Ramos-Martínez, A., Vicente-López, N., Sánchez-Romero, I., Padilla, B., Merino-Amador, P., Garnacho-Montero, J., ... Members of the CANDIPOP Project from GEIH-GEMICOMED (SEIMC) and REIPI (2017). Epidemiology and prognosis of candidaemia in elderly patients. Mycoses, 60(12), 808-817. https://doi.org/10.1111/myc.12677

Epidemiology and prognosis of candidaemia in elderly patients. / Ramos-Martínez, Antonio; Vicente-López, Natalia; Sánchez-Romero, Isabel; Padilla, Belén; Merino-Amador, Paloma; Garnacho-Montero, José; Ruiz-Camps, Isabel; Montejo, Miguel; Salavert, Miguel; Mensa, José; Cuenca-Estrella, Manuel; Members of the CANDIPOP Project from GEIH-GEMICOMED (SEIMC) and REIPI.

In: Mycoses, Vol. 60, No. 12, 12.2017, p. 808-817.

Research output: Contribution to journalArticle

Ramos-Martínez, A, Vicente-López, N, Sánchez-Romero, I, Padilla, B, Merino-Amador, P, Garnacho-Montero, J, Ruiz-Camps, I, Montejo, M, Salavert, M, Mensa, J, Cuenca-Estrella, M & Members of the CANDIPOP Project from GEIH-GEMICOMED (SEIMC) and REIPI 2017, 'Epidemiology and prognosis of candidaemia in elderly patients', Mycoses, vol. 60, no. 12, pp. 808-817. https://doi.org/10.1111/myc.12677
Ramos-Martínez A, Vicente-López N, Sánchez-Romero I, Padilla B, Merino-Amador P, Garnacho-Montero J et al. Epidemiology and prognosis of candidaemia in elderly patients. Mycoses. 2017 Dec;60(12):808-817. https://doi.org/10.1111/myc.12677
Ramos-Martínez, Antonio ; Vicente-López, Natalia ; Sánchez-Romero, Isabel ; Padilla, Belén ; Merino-Amador, Paloma ; Garnacho-Montero, José ; Ruiz-Camps, Isabel ; Montejo, Miguel ; Salavert, Miguel ; Mensa, José ; Cuenca-Estrella, Manuel ; Members of the CANDIPOP Project from GEIH-GEMICOMED (SEIMC) and REIPI. / Epidemiology and prognosis of candidaemia in elderly patients. In: Mycoses. 2017 ; Vol. 60, No. 12. pp. 808-817.
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