Epidemiology, clinical features and diagnostic work-up of cystic neoplasms of the pancreas: Interim analysis of the prospective PANCY survey

Raffaele Pezzilli; Elisabetta Buscarini; Tommaso Pollini; Deborah Bonamini; Giovanni Marchegiani; Stefano Crippa; Giulio Belfiori; Cosimo Sperti; Lucia Moletta; Gioia Pozza; Germana De Nucci; Giampiero Manes; Enzo D Mandelli; Riccardo Casadei; Claudio Ricci; Saverio Alicante; Claudia Vattiato; Silvia Carrara; Milena Di Leo; Carlo Fabbri; Silvia Giovanelli; Luca Barresi; Matteo Tacelli; Vincenzo G Mirante; Rita Conigliaro; Filippo Antonini; Giampiero Macarri; Luca Frulloni; Giulia De Marchi; Romano Sassatelli; Paolo Cecinato; Giovanna Del Vecchio Blanco; Andrea Galli; Angelo Pezzullo; Alberto Fantin; Massimo Graffeo; Mauro Frego; Domenico Stillittano; Fabio Monica; Bastianello Germanà; Gabriele Capurso; Mariano Quartini; Luigi Veneroni; Renato Cannizzaro; Massimo Falconi

doi:10.1016/j.dld.2020.02.003

Epidemiology, clinical features and diagnostic work-up of cystic neoplasms of the pancreas: Interim analysis of the prospective PANCY survey

Raffaele Pezzilli, Elisabetta Buscarini, Tommaso Pollini, Deborah Bonamini, Giovanni Marchegiani, Stefano Crippa, Giulio Belfiori, Cosimo Sperti, Lucia Moletta, Gioia Pozza, Germana De Nucci, Giampiero Manes, Enzo D Mandelli, Riccardo Casadei, Claudio Ricci, Saverio Alicante, Claudia Vattiato, Silvia Carrara, Milena Di Leo, Carlo FabbriSilvia Giovanelli, Luca Barresi, Matteo Tacelli, Vincenzo G Mirante, Rita Conigliaro, Filippo Antonini, Giampiero Macarri, Luca Frulloni, Giulia De Marchi, Romano Sassatelli, Paolo Cecinato, Giovanna Del Vecchio Blanco, Andrea Galli, Angelo Pezzullo, Alberto Fantin, Massimo Graffeo, Mauro Frego, Domenico Stillittano, Fabio Monica, Bastianello Germanà, Gabriele Capurso, Mariano Quartini, Luigi Veneroni, Renato Cannizzaro, Massimo Falconi

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: A prospective survey to evaluate the diagnostic workup of cystic pancreatic neoplasms (CPNs) according to the Italian guidelines.

METHODS: An online data sheet was built.

RESULTS: Fifteen of the 1385 patients (1.1%) had non cystic neoplastic lesions. Forty percent (518/1295) had at least one 1st degree relative affected by a solid tumor of the digestive and extra-digestive organs. Symptoms/signs associated with the cystic lesion were present in 24.5% of the patients. The cysts were localized in the head of the pancreas in 38.5% of patients. Of the 2370 examinations (1.7 examinations per patient) which were carried out for the diagnosis, magnetic resonance imaging was performed as a single test in 48.4% of patients and in combination with endoscopic ultrasound in 27% of the cases. Of the 1370 patients having CPNs, 89.9% had an intraductal papillary mucinous neoplasm (IPMN) (70.1% a branch duct IPMN, 6.2% a mixed type IPMN and 4.6% a main duct IPMN), 12.7% had a serous cystadenoma, 2.8% a mucinous cystadenoma, 1.5% a non-functioning cystic neuroendocrine neoplasm, 0.7% a solid-pseudopapillary cystic neoplasm, 0.3% a cystic adenocarcinoma, and 1.2% an undetermined cystic neoplasm. Seventy-eight (5.7%) patients were operated upon after the initial work-up.

CONCLUSIONS: This prospective study offers a reliable real-life picture of the diagnostic work-up CPN.

Original language	English
Pages (from-to)	547-554
Number of pages	8
Journal	Dig. Liver Dis.
Volume	52
Issue number	5
DOIs	https://doi.org/10.1016/j.dld.2020.02.003
Publication status	Published - May 2020

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Pezzilli, R., Buscarini, E., Pollini, T., Bonamini, D., Marchegiani, G., Crippa, S., Belfiori, G., Sperti, C., Moletta, L., Pozza, G., De Nucci, G., Manes, G., Mandelli, E. D., Casadei, R., Ricci, C., Alicante, S., Vattiato, C., Carrara, S., Di Leo, M., ... Falconi, M. (2020). Epidemiology, clinical features and diagnostic work-up of cystic neoplasms of the pancreas: Interim analysis of the prospective PANCY survey. Dig. Liver Dis., 52(5), 547-554. https://doi.org/10.1016/j.dld.2020.02.003

Epidemiology, clinical features and diagnostic work-up of cystic neoplasms of the pancreas : Interim analysis of the prospective PANCY survey. / Pezzilli, Raffaele; Buscarini, Elisabetta; Pollini, Tommaso; Bonamini, Deborah; Marchegiani, Giovanni; Crippa, Stefano; Belfiori, Giulio; Sperti, Cosimo; Moletta, Lucia; Pozza, Gioia; De Nucci, Germana; Manes, Giampiero; Mandelli, Enzo D; Casadei, Riccardo ; Ricci, Claudio; Alicante, Saverio; Vattiato, Claudia; Carrara, Silvia ; Di Leo, Milena; Fabbri, Carlo; Giovanelli, Silvia; Barresi, Luca; Tacelli, Matteo; Mirante, Vincenzo G; Conigliaro, Rita; Antonini, Filippo; Macarri, Giampiero; Frulloni, Luca; De Marchi, Giulia; Sassatelli, Romano ; Cecinato, Paolo; Del Vecchio Blanco, Giovanna; Galli, Andrea; Pezzullo, Angelo; Fantin, Alberto; Graffeo, Massimo; Frego, Mauro; Stillittano, Domenico; Monica, Fabio; Germanà, Bastianello; Capurso, Gabriele; Quartini, Mariano; Veneroni, Luigi; Cannizzaro, Renato ; Falconi, Massimo.

In: Dig. Liver Dis., Vol. 52, No. 5, 05.2020, p. 547-554.

Research output: Contribution to journal › Article › peer-review

Pezzilli, R, Buscarini, E, Pollini, T, Bonamini, D, Marchegiani, G, Crippa, S, Belfiori, G, Sperti, C, Moletta, L, Pozza, G, De Nucci, G, Manes, G, Mandelli, ED, Casadei, R , Ricci, C, Alicante, S, Vattiato, C, Carrara, S , Di Leo, M, Fabbri, C, Giovanelli, S, Barresi, L, Tacelli, M, Mirante, VG, Conigliaro, R, Antonini, F, Macarri, G, Frulloni, L, De Marchi, G, Sassatelli, R , Cecinato, P, Del Vecchio Blanco, G, Galli, A, Pezzullo, A, Fantin, A, Graffeo, M, Frego, M, Stillittano, D, Monica, F, Germanà, B, Capurso, G, Quartini, M, Veneroni, L, Cannizzaro, R & Falconi, M 2020, 'Epidemiology, clinical features and diagnostic work-up of cystic neoplasms of the pancreas: Interim analysis of the prospective PANCY survey', Dig. Liver Dis., vol. 52, no. 5, pp. 547-554. https://doi.org/10.1016/j.dld.2020.02.003

Pezzilli, Raffaele ; Buscarini, Elisabetta ; Pollini, Tommaso ; Bonamini, Deborah ; Marchegiani, Giovanni ; Crippa, Stefano ; Belfiori, Giulio ; Sperti, Cosimo ; Moletta, Lucia ; Pozza, Gioia ; De Nucci, Germana ; Manes, Giampiero ; Mandelli, Enzo D ; Casadei, Riccardo ; Ricci, Claudio ; Alicante, Saverio ; Vattiato, Claudia ; Carrara, Silvia ; Di Leo, Milena ; Fabbri, Carlo ; Giovanelli, Silvia ; Barresi, Luca ; Tacelli, Matteo ; Mirante, Vincenzo G ; Conigliaro, Rita ; Antonini, Filippo ; Macarri, Giampiero ; Frulloni, Luca ; De Marchi, Giulia ; Sassatelli, Romano ; Cecinato, Paolo ; Del Vecchio Blanco, Giovanna ; Galli, Andrea ; Pezzullo, Angelo ; Fantin, Alberto ; Graffeo, Massimo ; Frego, Mauro ; Stillittano, Domenico ; Monica, Fabio ; Germanà, Bastianello ; Capurso, Gabriele ; Quartini, Mariano ; Veneroni, Luigi ; Cannizzaro, Renato ; Falconi, Massimo. / Epidemiology, clinical features and diagnostic work-up of cystic neoplasms of the pancreas : Interim analysis of the prospective PANCY survey. In: Dig. Liver Dis. 2020 ; Vol. 52, No. 5. pp. 547-554.

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title = "Epidemiology, clinical features and diagnostic work-up of cystic neoplasms of the pancreas: Interim analysis of the prospective PANCY survey",

abstract = "INTRODUCTION: A prospective survey to evaluate the diagnostic workup of cystic pancreatic neoplasms (CPNs) according to the Italian guidelines.METHODS: An online data sheet was built.RESULTS: Fifteen of the 1385 patients (1.1%) had non cystic neoplastic lesions. Forty percent (518/1295) had at least one 1st degree relative affected by a solid tumor of the digestive and extra-digestive organs. Symptoms/signs associated with the cystic lesion were present in 24.5% of the patients. The cysts were localized in the head of the pancreas in 38.5% of patients. Of the 2370 examinations (1.7 examinations per patient) which were carried out for the diagnosis, magnetic resonance imaging was performed as a single test in 48.4% of patients and in combination with endoscopic ultrasound in 27% of the cases. Of the 1370 patients having CPNs, 89.9% had an intraductal papillary mucinous neoplasm (IPMN) (70.1% a branch duct IPMN, 6.2% a mixed type IPMN and 4.6% a main duct IPMN), 12.7% had a serous cystadenoma, 2.8% a mucinous cystadenoma, 1.5% a non-functioning cystic neuroendocrine neoplasm, 0.7% a solid-pseudopapillary cystic neoplasm, 0.3% a cystic adenocarcinoma, and 1.2% an undetermined cystic neoplasm. Seventy-eight (5.7%) patients were operated upon after the initial work-up.CONCLUSIONS: This prospective study offers a reliable real-life picture of the diagnostic work-up CPN.",

author = "Raffaele Pezzilli and Elisabetta Buscarini and Tommaso Pollini and Deborah Bonamini and Giovanni Marchegiani and Stefano Crippa and Giulio Belfiori and Cosimo Sperti and Lucia Moletta and Gioia Pozza and {De Nucci}, Germana and Giampiero Manes and Mandelli, {Enzo D} and Riccardo Casadei and Claudio Ricci and Saverio Alicante and Claudia Vattiato and Silvia Carrara and {Di Leo}, Milena and Carlo Fabbri and Silvia Giovanelli and Luca Barresi and Matteo Tacelli and Mirante, {Vincenzo G} and Rita Conigliaro and Filippo Antonini and Giampiero Macarri and Luca Frulloni and {De Marchi}, Giulia and Romano Sassatelli and Paolo Cecinato and {Del Vecchio Blanco}, Giovanna and Andrea Galli and Angelo Pezzullo and Alberto Fantin and Massimo Graffeo and Mauro Frego and Domenico Stillittano and Fabio Monica and Bastianello German{\`a} and Gabriele Capurso and Mariano Quartini and Luigi Veneroni and Renato Cannizzaro and Massimo Falconi",

year = "2020",

month = may,

doi = "10.1016/j.dld.2020.02.003",

language = "English",

volume = "52",

pages = "547--554",

journal = "Dig. Liver Dis.",

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TY - JOUR

T1 - Epidemiology, clinical features and diagnostic work-up of cystic neoplasms of the pancreas

T2 - Interim analysis of the prospective PANCY survey

AU - Pezzilli, Raffaele

AU - Buscarini, Elisabetta

AU - Pollini, Tommaso

AU - Bonamini, Deborah

AU - Marchegiani, Giovanni

AU - Crippa, Stefano

AU - Belfiori, Giulio

AU - Sperti, Cosimo

AU - Moletta, Lucia

AU - Pozza, Gioia

AU - De Nucci, Germana

AU - Manes, Giampiero

AU - Mandelli, Enzo D

AU - Casadei, Riccardo

AU - Ricci, Claudio

AU - Alicante, Saverio

AU - Vattiato, Claudia

AU - Carrara, Silvia

AU - Di Leo, Milena

AU - Fabbri, Carlo

AU - Giovanelli, Silvia

AU - Barresi, Luca

AU - Tacelli, Matteo

AU - Mirante, Vincenzo G

AU - Conigliaro, Rita

AU - Antonini, Filippo

AU - Macarri, Giampiero

AU - Frulloni, Luca

AU - De Marchi, Giulia

AU - Sassatelli, Romano

AU - Cecinato, Paolo

AU - Del Vecchio Blanco, Giovanna

AU - Galli, Andrea

AU - Pezzullo, Angelo

AU - Fantin, Alberto

AU - Graffeo, Massimo

AU - Frego, Mauro

AU - Stillittano, Domenico

AU - Monica, Fabio

AU - Germanà, Bastianello

AU - Capurso, Gabriele

AU - Quartini, Mariano

AU - Veneroni, Luigi

AU - Cannizzaro, Renato

AU - Falconi, Massimo

PY - 2020/5

Y1 - 2020/5

N2 - INTRODUCTION: A prospective survey to evaluate the diagnostic workup of cystic pancreatic neoplasms (CPNs) according to the Italian guidelines.METHODS: An online data sheet was built.RESULTS: Fifteen of the 1385 patients (1.1%) had non cystic neoplastic lesions. Forty percent (518/1295) had at least one 1st degree relative affected by a solid tumor of the digestive and extra-digestive organs. Symptoms/signs associated with the cystic lesion were present in 24.5% of the patients. The cysts were localized in the head of the pancreas in 38.5% of patients. Of the 2370 examinations (1.7 examinations per patient) which were carried out for the diagnosis, magnetic resonance imaging was performed as a single test in 48.4% of patients and in combination with endoscopic ultrasound in 27% of the cases. Of the 1370 patients having CPNs, 89.9% had an intraductal papillary mucinous neoplasm (IPMN) (70.1% a branch duct IPMN, 6.2% a mixed type IPMN and 4.6% a main duct IPMN), 12.7% had a serous cystadenoma, 2.8% a mucinous cystadenoma, 1.5% a non-functioning cystic neuroendocrine neoplasm, 0.7% a solid-pseudopapillary cystic neoplasm, 0.3% a cystic adenocarcinoma, and 1.2% an undetermined cystic neoplasm. Seventy-eight (5.7%) patients were operated upon after the initial work-up.CONCLUSIONS: This prospective study offers a reliable real-life picture of the diagnostic work-up CPN.

AB - INTRODUCTION: A prospective survey to evaluate the diagnostic workup of cystic pancreatic neoplasms (CPNs) according to the Italian guidelines.METHODS: An online data sheet was built.RESULTS: Fifteen of the 1385 patients (1.1%) had non cystic neoplastic lesions. Forty percent (518/1295) had at least one 1st degree relative affected by a solid tumor of the digestive and extra-digestive organs. Symptoms/signs associated with the cystic lesion were present in 24.5% of the patients. The cysts were localized in the head of the pancreas in 38.5% of patients. Of the 2370 examinations (1.7 examinations per patient) which were carried out for the diagnosis, magnetic resonance imaging was performed as a single test in 48.4% of patients and in combination with endoscopic ultrasound in 27% of the cases. Of the 1370 patients having CPNs, 89.9% had an intraductal papillary mucinous neoplasm (IPMN) (70.1% a branch duct IPMN, 6.2% a mixed type IPMN and 4.6% a main duct IPMN), 12.7% had a serous cystadenoma, 2.8% a mucinous cystadenoma, 1.5% a non-functioning cystic neuroendocrine neoplasm, 0.7% a solid-pseudopapillary cystic neoplasm, 0.3% a cystic adenocarcinoma, and 1.2% an undetermined cystic neoplasm. Seventy-eight (5.7%) patients were operated upon after the initial work-up.CONCLUSIONS: This prospective study offers a reliable real-life picture of the diagnostic work-up CPN.

U2 - 10.1016/j.dld.2020.02.003

DO - 10.1016/j.dld.2020.02.003

M3 - Article

C2 - 32122771

VL - 52

SP - 547

EP - 554

JO - Dig. Liver Dis.

JF - Dig. Liver Dis.

SN - 1590-8658

IS - 5

ER -