Epidemiology, clinical features and diagnostic work-up of cystic neoplasms of the pancreas: Interim analysis of the prospective PANCY survey

R. Pezzilli, E. Buscarini, T. Pollini, D. Bonamini, G. Marchegiani, S. Crippa, G. Belfiori, C. Sperti, L. Moletta, G. Pozza, G. De Nucci, G. Manes, E.D. Mandelli, R. Casadei, C. Ricci, S. Alicante, C. Vattiato, S. Carrara, M. Di Leo, C. FabbriS. Giovanelli, L. Barresi, M. Tacelli, V.G. Mirante, R. Conigliaro, F. Antonini, G. Macarri, L. Frulloni, G. De Marchi, R. Sassatelli, P. Cecinato, G. Del Vecchio Blanco, A. Galli, A. Pezzullo, A. Fantin, M. Graffeo, M. Frego, D. Stillittano, F. Monica, B. Germanà, G. Capurso, M. Quartini, L. Veneroni, R. Cannizzaro, M. Falconi

Research output: Contribution to journalArticlepeer-review


Introduction: A prospective survey to evaluate the diagnostic workup of cystic pancreatic neoplasms (CPNs) according to the Italian guidelines. Methods: An online data sheet was built. Results: Fifteen of the 1385 patients (1.1%) had non cystic neoplastic lesions. Forty percent (518/1295) had at least one 1st degree relative affected by a solid tumor of the digestive and extra-digestive organs. Symptoms/signs associated with the cystic lesion were present in 24.5% of the patients. The cysts were localized in the head of the pancreas in 38.5% of patients. Of the 2370 examinations (1.7 examinations per patient) which were carried out for the diagnosis, magnetic resonance imaging was performed as a single test in 48.4% of patients and in combination with endoscopic ultrasound in 27% of the cases. Of the 1370 patients having CPNs, 89.9% had an intraductal papillary mucinous neoplasm (IPMN) (70.1% a branch duct IPMN, 6.2% a mixed type IPMN and 4.6% a main duct IPMN), 12.7% had a serous cystadenoma, 2.8% a mucinous cystadenoma, 1.5% a non-functioning cystic neuroendocrine neoplasm, 0.7% a solid-pseudopapillary cystic neoplasm, 0.3% a cystic adenocarcinoma, and 1.2% an undetermined cystic neoplasm. Seventy-eight (5.7%) patients were operated upon after the initial work-up. Conclusions: This prospective study offers a reliable real-life picture of the diagnostic work-up CPN. © 2020 Editrice Gastroenterologica Italiana S.r.l.
Original languageEnglish
Pages (from-to)547-554
Number of pages8
JournalDig. Liver Dis.
Issue number5
Publication statusPublished - 2020


  • Biomarkers
  • Cystic neoplasm
  • Cytology
  • Endosonography
  • Epidemiology
  • Magnetic resonance imaging
  • Multidetector computed tomography
  • Pancreatic cyst
  • fluorodeoxyglucose
  • abdominal pain
  • acute pancreatitis
  • adult
  • aged
  • alcohol consumption
  • Article
  • cancer diagnosis
  • cancer epidemiology
  • cystadenoma
  • cystic neoplasm
  • diabetes mellitus
  • diarrhea
  • endoscopic ultrasonography
  • female
  • first-degree relative
  • follow up
  • gallstone
  • gastrointestinal endoscopy
  • health survey
  • human
  • intraductal papillary mucinous tumor
  • loss of appetite
  • major clinical study
  • male
  • nuclear magnetic resonance imaging
  • pancreas cancer
  • positron emission tomography
  • practice guideline
  • priority journal
  • prospective study
  • smoking habit


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