Epidemiology of AIDS-related tumours in developed and developing countries

L. Dal Maso, D. Serraino, S. Franceschi

Research output: Contribution to journalArticlepeer-review

Abstract

AIDS-associated illnesses include Kaposi's sarcoma (KS), non-Hodgkin's lymphoma (NHL), and, since 1993, invasive cervical cancer (ICC). Between 1988 and 1998, among AIDS cases reported in western Europe, 9.6% had KS and 3.9% had NHL as AIDS-defining illnesses. Between 1988 and 1998, the frequency of KS decreased from 13.4 to 6.4%, while NHL increased from 3.8 to 5.3%. Estimates of the relative risk (RR) of neoplasms in HIV-seropositive populations came from population-based cancer and AIDS registries linkage studies conducted in the United States, Italy and Australia and from a few cohort and case-control studies. In adults with HIV/AIDS, the RR was over 1000 for KS and ranged between 14 for low-grade NHL and over 300 for high-grade NHL. For Hodgkin's disease (HD), a consistent 10-fold higher RR was observed. For cervical and other anogenital tumours associated with human papilloma virus, risk increases were 2- and 12-fold, depending upon location. In Africa, the AIDS epidemic led to KS becoming the most common cancer type in men in several areas. The RR of AIDS-associated tumours were lower in Africa than those reported in western countries.

Original languageEnglish
Pages (from-to)1188-1201
Number of pages14
JournalEuropean Journal of Cancer
Volume37
Issue number10
DOIs
Publication statusPublished - 2001

Keywords

  • AIDS
  • Antiretroviral therapies
  • HIV
  • Hodgkin's disease
  • Invasive cervical cancer
  • Kaposi's sarcoma
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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