Epidemiology of and Risk Factors for BK Polyomavirus Replication and Nephropathy in Pediatric Renal Transplant Recipients: An International CERTAIN Registry Study

Britta Höcker, Lukas Schneble, Luisa Murer, Andrea Carraro, Lars Pape, Birgitta Kranz, Jun Oh, Matthias Zirngibl, Luca Dello Strologo, Anja Büscher, Lutz T Weber, Atif Awan, Martin Pohl, Martin Bald, Nikoleta Printza, Krisztina Rusai, Licia Peruzzi, Rezan Topaloglu, Alexander Fichtner, Kai KrupkaLennart Köster, Thomas Bruckner, Paul Schnitzler, Hans H Hirsch, Burkhard Tönshoff

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: BK polyomavirus-associated nephropathy (BKPyVAN) constitutes a serious cause of kidney allograft failure, but large-scale data in pediatric renal transplant recipients and a comprehensive analysis of specific risk factors are lacking.

METHODS: We analyzed data of 313 patients in the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN) registry, with an observation period of 3.3 years (range, 1 - 5). The net state of immunosuppressive therapy was assessed by the modified Vasudev score.

RESULTS: Presumptive BKPyVAN (defined as sustained (>3 weeks) high-level BK viremia >10 copies/mL) within 5 years posttransplant occurred in 49/311 (15.8%) of patients, and biopsy-proven BKPyVAN in 14/313 (4.5%). BKPyV viremia was observed in 115/311 patients (36.7%), of whom 11 of 115 (9.6%) developed viremia late, ie, after the second year posttransplant. In 6/48 patients (12.5%) with high-level viremia and in 3/14 (21.4%) with BKPyVAN this respective event occurred late. According to multivariable analysis, BKPyV viremia and/or BKPyVAN were associated with a higher net state of immunosuppression (OR 1.3, p<0.01) and with tacrolimus- vs. ciclosporin-based immunosuppression (OR 3.6, p<0.01), but also with younger recipient age (OR 1.1 per year younger, p<0.001) and obstructive uropathy (OR 12.4, p<0.01) as primary renal disease.

CONCLUSIONS: Uncontrolled BKPyV replication affects a significant proportion of pediatric renal transplant recipients, and is associated with unique features of epidemiology and risk factors such as young recipient age, obstructive uropathy and overall intensity of immunosuppressive therapy. BKPyV surveillance should be considered beyond 2 years posttransplant in pediatric patients at higher risk.

Original languageEnglish
JournalTransplantation
DOIs
Publication statusE-pub ahead of print - Aug 20 2018

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