Epidemiology of CKD regression in patients under nephrology care

Silvio Borrelli, Daniela Leonardis, Roberto Minutolo, Paolo Chiodini, Luca De Nicola, Ciro Esposito, Francesca Mallamaci, Carmine Zoccali, Giuseppe Conte

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Chronic Kidney Disease (CKD) regression is considered as an infrequent renal outcome, limited to early stages, and associated with higher mortality. However, prevalence, prognosis and the clinical correlates of CKD regression remain undefined in the setting of nephrology care. This is a multicenter prospective study in 1418 patients with established CKD (eGFR: 60-15 ml/min/1.73m2) under nephrology care in 47 outpatient clinics in Italy from a least one year. We defined CKD regressors as a ΔGFR ≥0 ml/min/1.73 m2/year. ΔGFR was estimated as the absolute difference between eGFR measured at baseline and at follow up visit after 18-24 months, respectively. Outcomes were End Stage Renal Disease (ESRD) and overall-causes Mortality.391 patients (27.6%) were identified as regressors as they showed an eGFR increase between the baseline visit in the renal clinic and the follow up visit. In multivariate regression analyses the regressor status was not associated with CKD stage. Low proteinuria was the main factor associated with CKD regression, accounting per se for 48% of the likelihood of this outcome. Lower systolic blood pressure, higher BMI and absence of autosomal polycystic disease (PKD) were additional predictors of CKD regression. In regressors, ESRD risk was 72% lower (HR: 0.28; 95% CI 0.14-0.57; p

Original languageEnglish
Article numbere0140138
JournalPLoS One
Volume10
Issue number10
DOIs
Publication statusPublished - Oct 13 2015

Fingerprint

Epidemiology
Nephrology
kidney diseases
Chronic Renal Insufficiency
epidemiology
Chronic Kidney Failure
Blood Pressure
Kidney
kidneys
Ambulatory Care Facilities
Proteinuria
Italy
Multicenter Studies
systolic blood pressure
prospective studies
Multivariate Analysis
Blood pressure
Regression Analysis
Prospective Studies
prognosis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Borrelli, S., Leonardis, D., Minutolo, R., Chiodini, P., De Nicola, L., Esposito, C., ... Conte, G. (2015). Epidemiology of CKD regression in patients under nephrology care. PLoS One, 10(10), [e0140138]. https://doi.org/10.1371/journal.pone.0140138

Epidemiology of CKD regression in patients under nephrology care. / Borrelli, Silvio; Leonardis, Daniela; Minutolo, Roberto; Chiodini, Paolo; De Nicola, Luca; Esposito, Ciro; Mallamaci, Francesca; Zoccali, Carmine; Conte, Giuseppe.

In: PLoS One, Vol. 10, No. 10, e0140138, 13.10.2015.

Research output: Contribution to journalArticle

Borrelli, S, Leonardis, D, Minutolo, R, Chiodini, P, De Nicola, L, Esposito, C, Mallamaci, F, Zoccali, C & Conte, G 2015, 'Epidemiology of CKD regression in patients under nephrology care', PLoS One, vol. 10, no. 10, e0140138. https://doi.org/10.1371/journal.pone.0140138
Borrelli S, Leonardis D, Minutolo R, Chiodini P, De Nicola L, Esposito C et al. Epidemiology of CKD regression in patients under nephrology care. PLoS One. 2015 Oct 13;10(10). e0140138. https://doi.org/10.1371/journal.pone.0140138
Borrelli, Silvio ; Leonardis, Daniela ; Minutolo, Roberto ; Chiodini, Paolo ; De Nicola, Luca ; Esposito, Ciro ; Mallamaci, Francesca ; Zoccali, Carmine ; Conte, Giuseppe. / Epidemiology of CKD regression in patients under nephrology care. In: PLoS One. 2015 ; Vol. 10, No. 10.
@article{08abc26c27084a428a1d8676f694abd5,
title = "Epidemiology of CKD regression in patients under nephrology care",
abstract = "Chronic Kidney Disease (CKD) regression is considered as an infrequent renal outcome, limited to early stages, and associated with higher mortality. However, prevalence, prognosis and the clinical correlates of CKD regression remain undefined in the setting of nephrology care. This is a multicenter prospective study in 1418 patients with established CKD (eGFR: 60-15 ml/min/1.73m2) under nephrology care in 47 outpatient clinics in Italy from a least one year. We defined CKD regressors as a ΔGFR ≥0 ml/min/1.73 m2/year. ΔGFR was estimated as the absolute difference between eGFR measured at baseline and at follow up visit after 18-24 months, respectively. Outcomes were End Stage Renal Disease (ESRD) and overall-causes Mortality.391 patients (27.6{\%}) were identified as regressors as they showed an eGFR increase between the baseline visit in the renal clinic and the follow up visit. In multivariate regression analyses the regressor status was not associated with CKD stage. Low proteinuria was the main factor associated with CKD regression, accounting per se for 48{\%} of the likelihood of this outcome. Lower systolic blood pressure, higher BMI and absence of autosomal polycystic disease (PKD) were additional predictors of CKD regression. In regressors, ESRD risk was 72{\%} lower (HR: 0.28; 95{\%} CI 0.14-0.57; p",
author = "Silvio Borrelli and Daniela Leonardis and Roberto Minutolo and Paolo Chiodini and {De Nicola}, Luca and Ciro Esposito and Francesca Mallamaci and Carmine Zoccali and Giuseppe Conte",
year = "2015",
month = "10",
day = "13",
doi = "10.1371/journal.pone.0140138",
language = "English",
volume = "10",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",

}

TY - JOUR

T1 - Epidemiology of CKD regression in patients under nephrology care

AU - Borrelli, Silvio

AU - Leonardis, Daniela

AU - Minutolo, Roberto

AU - Chiodini, Paolo

AU - De Nicola, Luca

AU - Esposito, Ciro

AU - Mallamaci, Francesca

AU - Zoccali, Carmine

AU - Conte, Giuseppe

PY - 2015/10/13

Y1 - 2015/10/13

N2 - Chronic Kidney Disease (CKD) regression is considered as an infrequent renal outcome, limited to early stages, and associated with higher mortality. However, prevalence, prognosis and the clinical correlates of CKD regression remain undefined in the setting of nephrology care. This is a multicenter prospective study in 1418 patients with established CKD (eGFR: 60-15 ml/min/1.73m2) under nephrology care in 47 outpatient clinics in Italy from a least one year. We defined CKD regressors as a ΔGFR ≥0 ml/min/1.73 m2/year. ΔGFR was estimated as the absolute difference between eGFR measured at baseline and at follow up visit after 18-24 months, respectively. Outcomes were End Stage Renal Disease (ESRD) and overall-causes Mortality.391 patients (27.6%) were identified as regressors as they showed an eGFR increase between the baseline visit in the renal clinic and the follow up visit. In multivariate regression analyses the regressor status was not associated with CKD stage. Low proteinuria was the main factor associated with CKD regression, accounting per se for 48% of the likelihood of this outcome. Lower systolic blood pressure, higher BMI and absence of autosomal polycystic disease (PKD) were additional predictors of CKD regression. In regressors, ESRD risk was 72% lower (HR: 0.28; 95% CI 0.14-0.57; p

AB - Chronic Kidney Disease (CKD) regression is considered as an infrequent renal outcome, limited to early stages, and associated with higher mortality. However, prevalence, prognosis and the clinical correlates of CKD regression remain undefined in the setting of nephrology care. This is a multicenter prospective study in 1418 patients with established CKD (eGFR: 60-15 ml/min/1.73m2) under nephrology care in 47 outpatient clinics in Italy from a least one year. We defined CKD regressors as a ΔGFR ≥0 ml/min/1.73 m2/year. ΔGFR was estimated as the absolute difference between eGFR measured at baseline and at follow up visit after 18-24 months, respectively. Outcomes were End Stage Renal Disease (ESRD) and overall-causes Mortality.391 patients (27.6%) were identified as regressors as they showed an eGFR increase between the baseline visit in the renal clinic and the follow up visit. In multivariate regression analyses the regressor status was not associated with CKD stage. Low proteinuria was the main factor associated with CKD regression, accounting per se for 48% of the likelihood of this outcome. Lower systolic blood pressure, higher BMI and absence of autosomal polycystic disease (PKD) were additional predictors of CKD regression. In regressors, ESRD risk was 72% lower (HR: 0.28; 95% CI 0.14-0.57; p

UR - http://www.scopus.com/inward/record.url?scp=84948765984&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948765984&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0140138

DO - 10.1371/journal.pone.0140138

M3 - Article

AN - SCOPUS:84948765984

VL - 10

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 10

M1 - e0140138

ER -