Epidemiology of clinical trials of medicines in respiratory diseases in Europe and Italy

Roberta Bodini, Pierachille Santus, Fabiano Di Marco, Stefano Aliberti, Stefano Centanni, Francesco Blasi, Andrea Rizzi, Giuseppe Recchia

Research output: Contribution to journalShort surveypeer-review


Background Clinical trials play a key role in advancing medical knowledge, improving patient care and promoting economic growth in Europe. We have assessed the clinical trial activity in any respiratory diseases in Europe, with a specific focus on Italy. Methods Information from public sources (EFPIA, clinicaltrials.gov, clinicaltrialsregister. eu, AIFA) was used to describe clinical trial activity of in respiratory diseases in Europe and by country. Results In 2015, 3908 clinical trials were reported in Europe, 386 in respiratory diseases (9.9%). Germany was the first country both as absolute number (76 trials) and as percentage within country trials (14%), followed by Poland. Spain, Italy and France were the countries with the lowest number and percentage of trials in respiratory diseases. In 2013, the Italian Drug Agency reported 9 trials with respiratory compounds in Italy (2.1% of overall trials, 12ˆ position in the therapeutic area rank), 33% in phase 2 and 66% in phase 3. No phase 1 or phase 4 trials were reported for respiratory trials. Prevalence of respiratory trials by non-profit sponsors (28.3%) was below the average for the country (38.3%). Conclusions Europe has a greater potential for clinical research on drugs for respiratory diseases, particularly in countries with less activity, such as Spain, France and Italy, that should identify and implement actions to increase attractiveness for clinical trials of drugs.

Original languageEnglish
Pages (from-to)8-11
Number of pages4
JournalRespiratory Medicine
Publication statusPublished - Apr 1 2017

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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