Epidemiology of cryptosporidiosis among European AIDS patients

Court Pedersen, S. Danner, A. Lazzarin, M. P. Glauser, R. Weber, C. Katlama, S. E. Barton, J. D. Lundgren, N. Clumeck, S. DeWit, B. Sommereijns, J. O. Nielsen, J. Lundgren, T. Nielsen, G. Jensen, P. Skinhøj, K. Bentsen, J. Gerstoft, M. Melbye, A. Ranki & 77 others S. L. Valle, C. Katlama, P. Berlureau, M. Dietrich, S. Schwander, F. D. Goebel, J. Kosmidis, G. Stergiou, T. Gouzia, A. Papadopoulos, D. Banhegyi, F. Mulcahy, I. Yust, Z. Ben-Ishai, Z. Bentwich, T. Sacks, S. Maayan, S. Vella, A. Chiesi, F. Ancarani, G. Scalise, A. Bertaggia, E. Francavilla, G. Calonghi, A. Cargnel, M. Arlotti, R. Ciammarughi, A. Colomba, F. DeLalla, P. Fassio, A. Ferlini, F. Fiaccadori, G. Pasetti, F. Giannelli, W. Grillone, A. Lazzarin, A. D'Arminio Monforte, E. Mignani, A. Nunnari, L. Ortona, G. Panichi, S. Pauluzzi, N. Piersantelli, S. Ranieri, P. Ricciardiello, B. Roscioli, M. Soranzo, R. Hemmer, S. Danner, Peter Reiss, F. Antunes, R. Proenca, J. González-Lahoz, Rosa Polo, B. Clotet, J. Gatell, E. Buira, J. Miró, P. Pehrson, R. Lüthy, B. Ledergerber, C. Olsson, M. Glauser, B. Hirschel, A. Johnson, S. Hawkes, A. Phillips, S. Barton, J. Morcinek, A. Pinching, D. Coleman, I. Gjørup, J. Lundgren, J. Nielsen, C. Nieport, L. Teglbjaerg, A. Thornval

Research output: Contribution to journalArticle

Abstract

Objective: To study epidemiology and possible risk factors associated with the development of cryptosporidiosis among European patients with AIDS. Methods: An inception cohort of 6548 patients with AIDS, consecutively diagnosed from 1979 to 1989, from 52 centres in 17 European countries was studied. Data on all AIDS defining events were collected retrospectively from patients' clinical records. Kaplan-Meier estimates, log rank tests and Cox proportional hazard models were used to examine for possible risk factors associated with cryptosporidiosis. Results: Cryptosporidiosis was diagnosed in 432 (6.6%) patients, 216 at time of the AIDS diagnosis and 216 during follow-up. The probability of being diagnosed with cryptosporidiosis at AIDS diagnosis was significantly lower for intravenous drug users (1.3%) than for homosexual men (4.1%) and for patients belonging to other transmission categories (4.0%) (p <0.001). The probability was also higher for patients from Central Europe compared with patients from South Europe (4.1% versus 2.5%, p = 0.005). The rate of developing cryptosporidiosis after the diagnosis of AIDS was 3 per 100 patient years of follow-up. The rate was significantly lower for intravenous drug users than for homosexual men (relative risk 0.34, 95% confidence limits 0.22-0.54) and for women compared with men (RR 0.43 (0.21-0.87)). The risk was higher in North Europe than in South and Central Europe. In a multivariate analysis only transmission category remained a significant predictor for the development of cryptosporidiosis. Conclusion: The development of cryptosporidiosis in AIDS patients may be associated with sexual risk behaviour.

Original languageEnglish
Pages (from-to)128-131
Number of pages4
JournalSexually Transmitted Infections
Volume72
Issue number2
DOIs
Publication statusPublished - Apr 1996

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Cryptosporidiosis
Acquired Immunodeficiency Syndrome
Epidemiology
Drug Users
Kaplan-Meier Estimate
Risk-Taking
Proportional Hazards Models
Sexual Behavior
Multivariate Analysis

Keywords

  • AIDS
  • Cryptosporidia
  • Cryptosporidiosis
  • Epidemiology
  • HIV

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

Pedersen, C., Danner, S., Lazzarin, A., Glauser, M. P., Weber, R., Katlama, C., ... Thornval, A. (1996). Epidemiology of cryptosporidiosis among European AIDS patients. Sexually Transmitted Infections, 72(2), 128-131. https://doi.org/10.1136/sti.72.2.128

Epidemiology of cryptosporidiosis among European AIDS patients. / Pedersen, Court; Danner, S.; Lazzarin, A.; Glauser, M. P.; Weber, R.; Katlama, C.; Barton, S. E.; Lundgren, J. D.; Clumeck, N.; DeWit, S.; Sommereijns, B.; Nielsen, J. O.; Lundgren, J.; Nielsen, T.; Jensen, G.; Skinhøj, P.; Bentsen, K.; Gerstoft, J.; Melbye, M.; Ranki, A.; Valle, S. L.; Katlama, C.; Berlureau, P.; Dietrich, M.; Schwander, S.; Goebel, F. D.; Kosmidis, J.; Stergiou, G.; Gouzia, T.; Papadopoulos, A.; Banhegyi, D.; Mulcahy, F.; Yust, I.; Ben-Ishai, Z.; Bentwich, Z.; Sacks, T.; Maayan, S.; Vella, S.; Chiesi, A.; Ancarani, F.; Scalise, G.; Bertaggia, A.; Francavilla, E.; Calonghi, G.; Cargnel, A.; Arlotti, M.; Ciammarughi, R.; Colomba, A.; DeLalla, F.; Fassio, P.; Ferlini, A.; Fiaccadori, F.; Pasetti, G.; Giannelli, F.; Grillone, W.; Lazzarin, A.; D'Arminio Monforte, A.; Mignani, E.; Nunnari, A.; Ortona, L.; Panichi, G.; Pauluzzi, S.; Piersantelli, N.; Ranieri, S.; Ricciardiello, P.; Roscioli, B.; Soranzo, M.; Hemmer, R.; Danner, S.; Reiss, Peter; Antunes, F.; Proenca, R.; González-Lahoz, J.; Polo, Rosa; Clotet, B.; Gatell, J.; Buira, E.; Miró, J.; Pehrson, P.; Lüthy, R.; Ledergerber, B.; Olsson, C.; Glauser, M.; Hirschel, B.; Johnson, A.; Hawkes, S.; Phillips, A.; Barton, S.; Morcinek, J.; Pinching, A.; Coleman, D.; Gjørup, I.; Lundgren, J.; Nielsen, J.; Nieport, C.; Teglbjaerg, L.; Thornval, A.

In: Sexually Transmitted Infections, Vol. 72, No. 2, 04.1996, p. 128-131.

Research output: Contribution to journalArticle

Pedersen, C, Danner, S, Lazzarin, A, Glauser, MP, Weber, R, Katlama, C, Barton, SE, Lundgren, JD, Clumeck, N, DeWit, S, Sommereijns, B, Nielsen, JO, Lundgren, J, Nielsen, T, Jensen, G, Skinhøj, P, Bentsen, K, Gerstoft, J, Melbye, M, Ranki, A, Valle, SL, Katlama, C, Berlureau, P, Dietrich, M, Schwander, S, Goebel, FD, Kosmidis, J, Stergiou, G, Gouzia, T, Papadopoulos, A, Banhegyi, D, Mulcahy, F, Yust, I, Ben-Ishai, Z, Bentwich, Z, Sacks, T, Maayan, S, Vella, S, Chiesi, A, Ancarani, F, Scalise, G, Bertaggia, A, Francavilla, E, Calonghi, G, Cargnel, A, Arlotti, M, Ciammarughi, R, Colomba, A, DeLalla, F, Fassio, P, Ferlini, A, Fiaccadori, F, Pasetti, G, Giannelli, F, Grillone, W, Lazzarin, A, D'Arminio Monforte, A, Mignani, E, Nunnari, A, Ortona, L, Panichi, G, Pauluzzi, S, Piersantelli, N, Ranieri, S, Ricciardiello, P, Roscioli, B, Soranzo, M, Hemmer, R, Danner, S, Reiss, P, Antunes, F, Proenca, R, González-Lahoz, J, Polo, R, Clotet, B, Gatell, J, Buira, E, Miró, J, Pehrson, P, Lüthy, R, Ledergerber, B, Olsson, C, Glauser, M, Hirschel, B, Johnson, A, Hawkes, S, Phillips, A, Barton, S, Morcinek, J, Pinching, A, Coleman, D, Gjørup, I, Lundgren, J, Nielsen, J, Nieport, C, Teglbjaerg, L & Thornval, A 1996, 'Epidemiology of cryptosporidiosis among European AIDS patients', Sexually Transmitted Infections, vol. 72, no. 2, pp. 128-131. https://doi.org/10.1136/sti.72.2.128
Pedersen C, Danner S, Lazzarin A, Glauser MP, Weber R, Katlama C et al. Epidemiology of cryptosporidiosis among European AIDS patients. Sexually Transmitted Infections. 1996 Apr;72(2):128-131. https://doi.org/10.1136/sti.72.2.128
Pedersen, Court ; Danner, S. ; Lazzarin, A. ; Glauser, M. P. ; Weber, R. ; Katlama, C. ; Barton, S. E. ; Lundgren, J. D. ; Clumeck, N. ; DeWit, S. ; Sommereijns, B. ; Nielsen, J. O. ; Lundgren, J. ; Nielsen, T. ; Jensen, G. ; Skinhøj, P. ; Bentsen, K. ; Gerstoft, J. ; Melbye, M. ; Ranki, A. ; Valle, S. L. ; Katlama, C. ; Berlureau, P. ; Dietrich, M. ; Schwander, S. ; Goebel, F. D. ; Kosmidis, J. ; Stergiou, G. ; Gouzia, T. ; Papadopoulos, A. ; Banhegyi, D. ; Mulcahy, F. ; Yust, I. ; Ben-Ishai, Z. ; Bentwich, Z. ; Sacks, T. ; Maayan, S. ; Vella, S. ; Chiesi, A. ; Ancarani, F. ; Scalise, G. ; Bertaggia, A. ; Francavilla, E. ; Calonghi, G. ; Cargnel, A. ; Arlotti, M. ; Ciammarughi, R. ; Colomba, A. ; DeLalla, F. ; Fassio, P. ; Ferlini, A. ; Fiaccadori, F. ; Pasetti, G. ; Giannelli, F. ; Grillone, W. ; Lazzarin, A. ; D'Arminio Monforte, A. ; Mignani, E. ; Nunnari, A. ; Ortona, L. ; Panichi, G. ; Pauluzzi, S. ; Piersantelli, N. ; Ranieri, S. ; Ricciardiello, P. ; Roscioli, B. ; Soranzo, M. ; Hemmer, R. ; Danner, S. ; Reiss, Peter ; Antunes, F. ; Proenca, R. ; González-Lahoz, J. ; Polo, Rosa ; Clotet, B. ; Gatell, J. ; Buira, E. ; Miró, J. ; Pehrson, P. ; Lüthy, R. ; Ledergerber, B. ; Olsson, C. ; Glauser, M. ; Hirschel, B. ; Johnson, A. ; Hawkes, S. ; Phillips, A. ; Barton, S. ; Morcinek, J. ; Pinching, A. ; Coleman, D. ; Gjørup, I. ; Lundgren, J. ; Nielsen, J. ; Nieport, C. ; Teglbjaerg, L. ; Thornval, A. / Epidemiology of cryptosporidiosis among European AIDS patients. In: Sexually Transmitted Infections. 1996 ; Vol. 72, No. 2. pp. 128-131.
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abstract = "Objective: To study epidemiology and possible risk factors associated with the development of cryptosporidiosis among European patients with AIDS. Methods: An inception cohort of 6548 patients with AIDS, consecutively diagnosed from 1979 to 1989, from 52 centres in 17 European countries was studied. Data on all AIDS defining events were collected retrospectively from patients' clinical records. Kaplan-Meier estimates, log rank tests and Cox proportional hazard models were used to examine for possible risk factors associated with cryptosporidiosis. Results: Cryptosporidiosis was diagnosed in 432 (6.6{\%}) patients, 216 at time of the AIDS diagnosis and 216 during follow-up. The probability of being diagnosed with cryptosporidiosis at AIDS diagnosis was significantly lower for intravenous drug users (1.3{\%}) than for homosexual men (4.1{\%}) and for patients belonging to other transmission categories (4.0{\%}) (p <0.001). The probability was also higher for patients from Central Europe compared with patients from South Europe (4.1{\%} versus 2.5{\%}, p = 0.005). The rate of developing cryptosporidiosis after the diagnosis of AIDS was 3 per 100 patient years of follow-up. The rate was significantly lower for intravenous drug users than for homosexual men (relative risk 0.34, 95{\%} confidence limits 0.22-0.54) and for women compared with men (RR 0.43 (0.21-0.87)). The risk was higher in North Europe than in South and Central Europe. In a multivariate analysis only transmission category remained a significant predictor for the development of cryptosporidiosis. Conclusion: The development of cryptosporidiosis in AIDS patients may be associated with sexual risk behaviour.",
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TY - JOUR

T1 - Epidemiology of cryptosporidiosis among European AIDS patients

AU - Pedersen, Court

AU - Danner, S.

AU - Lazzarin, A.

AU - Glauser, M. P.

AU - Weber, R.

AU - Katlama, C.

AU - Barton, S. E.

AU - Lundgren, J. D.

AU - Clumeck, N.

AU - DeWit, S.

AU - Sommereijns, B.

AU - Nielsen, J. O.

AU - Lundgren, J.

AU - Nielsen, T.

AU - Jensen, G.

AU - Skinhøj, P.

AU - Bentsen, K.

AU - Gerstoft, J.

AU - Melbye, M.

AU - Ranki, A.

AU - Valle, S. L.

AU - Katlama, C.

AU - Berlureau, P.

AU - Dietrich, M.

AU - Schwander, S.

AU - Goebel, F. D.

AU - Kosmidis, J.

AU - Stergiou, G.

AU - Gouzia, T.

AU - Papadopoulos, A.

AU - Banhegyi, D.

AU - Mulcahy, F.

AU - Yust, I.

AU - Ben-Ishai, Z.

AU - Bentwich, Z.

AU - Sacks, T.

AU - Maayan, S.

AU - Vella, S.

AU - Chiesi, A.

AU - Ancarani, F.

AU - Scalise, G.

AU - Bertaggia, A.

AU - Francavilla, E.

AU - Calonghi, G.

AU - Cargnel, A.

AU - Arlotti, M.

AU - Ciammarughi, R.

AU - Colomba, A.

AU - DeLalla, F.

AU - Fassio, P.

AU - Ferlini, A.

AU - Fiaccadori, F.

AU - Pasetti, G.

AU - Giannelli, F.

AU - Grillone, W.

AU - Lazzarin, A.

AU - D'Arminio Monforte, A.

AU - Mignani, E.

AU - Nunnari, A.

AU - Ortona, L.

AU - Panichi, G.

AU - Pauluzzi, S.

AU - Piersantelli, N.

AU - Ranieri, S.

AU - Ricciardiello, P.

AU - Roscioli, B.

AU - Soranzo, M.

AU - Hemmer, R.

AU - Danner, S.

AU - Reiss, Peter

AU - Antunes, F.

AU - Proenca, R.

AU - González-Lahoz, J.

AU - Polo, Rosa

AU - Clotet, B.

AU - Gatell, J.

AU - Buira, E.

AU - Miró, J.

AU - Pehrson, P.

AU - Lüthy, R.

AU - Ledergerber, B.

AU - Olsson, C.

AU - Glauser, M.

AU - Hirschel, B.

AU - Johnson, A.

AU - Hawkes, S.

AU - Phillips, A.

AU - Barton, S.

AU - Morcinek, J.

AU - Pinching, A.

AU - Coleman, D.

AU - Gjørup, I.

AU - Lundgren, J.

AU - Nielsen, J.

AU - Nieport, C.

AU - Teglbjaerg, L.

AU - Thornval, A.

PY - 1996/4

Y1 - 1996/4

N2 - Objective: To study epidemiology and possible risk factors associated with the development of cryptosporidiosis among European patients with AIDS. Methods: An inception cohort of 6548 patients with AIDS, consecutively diagnosed from 1979 to 1989, from 52 centres in 17 European countries was studied. Data on all AIDS defining events were collected retrospectively from patients' clinical records. Kaplan-Meier estimates, log rank tests and Cox proportional hazard models were used to examine for possible risk factors associated with cryptosporidiosis. Results: Cryptosporidiosis was diagnosed in 432 (6.6%) patients, 216 at time of the AIDS diagnosis and 216 during follow-up. The probability of being diagnosed with cryptosporidiosis at AIDS diagnosis was significantly lower for intravenous drug users (1.3%) than for homosexual men (4.1%) and for patients belonging to other transmission categories (4.0%) (p <0.001). The probability was also higher for patients from Central Europe compared with patients from South Europe (4.1% versus 2.5%, p = 0.005). The rate of developing cryptosporidiosis after the diagnosis of AIDS was 3 per 100 patient years of follow-up. The rate was significantly lower for intravenous drug users than for homosexual men (relative risk 0.34, 95% confidence limits 0.22-0.54) and for women compared with men (RR 0.43 (0.21-0.87)). The risk was higher in North Europe than in South and Central Europe. In a multivariate analysis only transmission category remained a significant predictor for the development of cryptosporidiosis. Conclusion: The development of cryptosporidiosis in AIDS patients may be associated with sexual risk behaviour.

AB - Objective: To study epidemiology and possible risk factors associated with the development of cryptosporidiosis among European patients with AIDS. Methods: An inception cohort of 6548 patients with AIDS, consecutively diagnosed from 1979 to 1989, from 52 centres in 17 European countries was studied. Data on all AIDS defining events were collected retrospectively from patients' clinical records. Kaplan-Meier estimates, log rank tests and Cox proportional hazard models were used to examine for possible risk factors associated with cryptosporidiosis. Results: Cryptosporidiosis was diagnosed in 432 (6.6%) patients, 216 at time of the AIDS diagnosis and 216 during follow-up. The probability of being diagnosed with cryptosporidiosis at AIDS diagnosis was significantly lower for intravenous drug users (1.3%) than for homosexual men (4.1%) and for patients belonging to other transmission categories (4.0%) (p <0.001). The probability was also higher for patients from Central Europe compared with patients from South Europe (4.1% versus 2.5%, p = 0.005). The rate of developing cryptosporidiosis after the diagnosis of AIDS was 3 per 100 patient years of follow-up. The rate was significantly lower for intravenous drug users than for homosexual men (relative risk 0.34, 95% confidence limits 0.22-0.54) and for women compared with men (RR 0.43 (0.21-0.87)). The risk was higher in North Europe than in South and Central Europe. In a multivariate analysis only transmission category remained a significant predictor for the development of cryptosporidiosis. Conclusion: The development of cryptosporidiosis in AIDS patients may be associated with sexual risk behaviour.

KW - AIDS

KW - Cryptosporidia

KW - Cryptosporidiosis

KW - Epidemiology

KW - HIV

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U2 - 10.1136/sti.72.2.128

DO - 10.1136/sti.72.2.128

M3 - Article

VL - 72

SP - 128

EP - 131

JO - Sexually Transmitted Infections

JF - Sexually Transmitted Infections

SN - 1368-4973

IS - 2

ER -