Epidemiology of endometriosis and its comorbidities

F. Parazzini, G. Esposito, L. Tozzi, S. Noli, S. Bianchi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Genetic profile, inflammation, hormonal activity, menstrual cyclicity, organochlorine burden, prostaglandin metabolism and immunological factors have been suggested to play a role in the establishment and development of endometriosis. From the epidemiological perspective, several risk factors have been studied to suggest or support the different aetiological hypotheses.Social class and family history apart, the factors most consistently associated with endometriosis are early age at menarche and long and heavy menstrual cycles. These menstrual characteristics (together with nulliparity) reflect increased exposure to menstruation. The other main risk factors are pigmentary traits and sun habits, alcohol intake, use of oral contraceptives, and environmental factors such as exposure to polychlorinated biphenyls and dioxin. All of these factors support a potential role of hormonal mileau and inflammation in the pathogenesis of endometriosis.There is a clear association between endometriosis and gastrointestinal and immunological diseases, ovarian cancer and other gynaecological cancers, and thyroid cancer.

Original languageEnglish
Pages (from-to)3-7
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume209
DOIs
Publication statusPublished - 2017

Fingerprint

Endometriosis
Comorbidity
Epidemiology
Thyroid Neoplasms
Inflammation
Menarche
Dioxins
Menstruation
Gastrointestinal Diseases
Polychlorinated Biphenyls
Immune System Diseases
Immunologic Factors
Solar System
Periodicity
Menstrual Cycle
Oral Contraceptives
Parity
Social Class
Ovarian Neoplasms
Habits

Keywords

  • Comorbidities
  • Endometriosis
  • Epidemiology
  • Risk factors

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Epidemiology of endometriosis and its comorbidities. / Parazzini, F.; Esposito, G.; Tozzi, L.; Noli, S.; Bianchi, S.

In: European Journal of Obstetrics and Gynecology and Reproductive Biology, Vol. 209, 2017, p. 3-7.

Research output: Contribution to journalArticle

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