Epidemiology of gout and hyperuricaemia in Italy during the years 2005-2009: A nationwide population-based study

Gianluca Trifirò, Paolo Morabito, Lorenzo Cavagna, Carmen Ferrajolo, Serena Pecchioli, Monica Simonetti, Elisa Bianchini, Gerardo Medea, Claudio Cricelli, Achille P. Caputi, Giampiero Mazzaglia

Research output: Contribution to journalArticle

Abstract

Objective: To assess the epidemiology of gout and hyperuricaemia in the Italian general population during the years 2005-2009. Methods: Using the Italian primary care database (Health Search/CSD Longitudinal Patient Database), the prevalence, incidence and recurrence rates of gout and/ or hyperuricaemia (serum urate level >360 mmol/l (6 mg/dl)) in outpatients aged ≥18 years during the years 2005-2009 were estimated. Rates together with 95% CI were measured overall and stratified by age, gender and calendar year. The characteristics of patients with newly diagnosed gout and hyperuricaemia were investigated and compared with the general population. Results: The prevalence of gout increased from 6.7 per 1000 inhabitants in 2005 to 9.1 per 1000 inhabitants in 2009. It increased with advancing age and was fourfold higher in men. A similar trend was observed for asymptomatic hyperuricaemia (85.4 per 1000 inhabitants in 2005 vs 119.3 per 1000 inhabitants in 2009). The incidence of gout remained stable during the observation years (0.93 per 1000 person years in 2005 vs 0.95 in 2009). Recurrent episode rate was 19.1% during the first year following the first gout attack and 31.6% during the following 5 years. Advanced age, increased levels of uric acid, nephrolithiasis and concomitant use of ciclosporin were the main predictors of recurrence of gout attacks. Conclusion: The prevalence of gout and hyperuricaemia increased in Italy from 2005 to 2009. A high recurrence rate for gout attack was observed during the first year following the first episode. Early management of hyperuricaemia in patients at higher risk of recurrent gout attack should be considered in primary care.

Original languageEnglish
Pages (from-to)694-700
Number of pages7
JournalAnnals of the Rheumatic Diseases
Volume72
Issue number5
DOIs
Publication statusPublished - May 2013

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Epidemiology
Gout
Uric Acid
Italy
Cyclosporine
Population
Health
Recurrence
Primary Health Care
Databases
Nephrolithiasis
Incidence
Outpatients
Observation

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

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Epidemiology of gout and hyperuricaemia in Italy during the years 2005-2009 : A nationwide population-based study. / Trifirò, Gianluca; Morabito, Paolo; Cavagna, Lorenzo; Ferrajolo, Carmen; Pecchioli, Serena; Simonetti, Monica; Bianchini, Elisa; Medea, Gerardo; Cricelli, Claudio; Caputi, Achille P.; Mazzaglia, Giampiero.

In: Annals of the Rheumatic Diseases, Vol. 72, No. 5, 05.2013, p. 694-700.

Research output: Contribution to journalArticle

Trifirò, G, Morabito, P, Cavagna, L, Ferrajolo, C, Pecchioli, S, Simonetti, M, Bianchini, E, Medea, G, Cricelli, C, Caputi, AP & Mazzaglia, G 2013, 'Epidemiology of gout and hyperuricaemia in Italy during the years 2005-2009: A nationwide population-based study', Annals of the Rheumatic Diseases, vol. 72, no. 5, pp. 694-700. https://doi.org/10.1136/annrheumdis-2011-201254
Trifirò, Gianluca ; Morabito, Paolo ; Cavagna, Lorenzo ; Ferrajolo, Carmen ; Pecchioli, Serena ; Simonetti, Monica ; Bianchini, Elisa ; Medea, Gerardo ; Cricelli, Claudio ; Caputi, Achille P. ; Mazzaglia, Giampiero. / Epidemiology of gout and hyperuricaemia in Italy during the years 2005-2009 : A nationwide population-based study. In: Annals of the Rheumatic Diseases. 2013 ; Vol. 72, No. 5. pp. 694-700.
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abstract = "Objective: To assess the epidemiology of gout and hyperuricaemia in the Italian general population during the years 2005-2009. Methods: Using the Italian primary care database (Health Search/CSD Longitudinal Patient Database), the prevalence, incidence and recurrence rates of gout and/ or hyperuricaemia (serum urate level >360 mmol/l (6 mg/dl)) in outpatients aged ≥18 years during the years 2005-2009 were estimated. Rates together with 95{\%} CI were measured overall and stratified by age, gender and calendar year. The characteristics of patients with newly diagnosed gout and hyperuricaemia were investigated and compared with the general population. Results: The prevalence of gout increased from 6.7 per 1000 inhabitants in 2005 to 9.1 per 1000 inhabitants in 2009. It increased with advancing age and was fourfold higher in men. A similar trend was observed for asymptomatic hyperuricaemia (85.4 per 1000 inhabitants in 2005 vs 119.3 per 1000 inhabitants in 2009). The incidence of gout remained stable during the observation years (0.93 per 1000 person years in 2005 vs 0.95 in 2009). Recurrent episode rate was 19.1{\%} during the first year following the first gout attack and 31.6{\%} during the following 5 years. Advanced age, increased levels of uric acid, nephrolithiasis and concomitant use of ciclosporin were the main predictors of recurrence of gout attacks. Conclusion: The prevalence of gout and hyperuricaemia increased in Italy from 2005 to 2009. A high recurrence rate for gout attack was observed during the first year following the first episode. Early management of hyperuricaemia in patients at higher risk of recurrent gout attack should be considered in primary care.",
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AU - Trifirò, Gianluca

AU - Morabito, Paolo

AU - Cavagna, Lorenzo

AU - Ferrajolo, Carmen

AU - Pecchioli, Serena

AU - Simonetti, Monica

AU - Bianchini, Elisa

AU - Medea, Gerardo

AU - Cricelli, Claudio

AU - Caputi, Achille P.

AU - Mazzaglia, Giampiero

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N2 - Objective: To assess the epidemiology of gout and hyperuricaemia in the Italian general population during the years 2005-2009. Methods: Using the Italian primary care database (Health Search/CSD Longitudinal Patient Database), the prevalence, incidence and recurrence rates of gout and/ or hyperuricaemia (serum urate level >360 mmol/l (6 mg/dl)) in outpatients aged ≥18 years during the years 2005-2009 were estimated. Rates together with 95% CI were measured overall and stratified by age, gender and calendar year. The characteristics of patients with newly diagnosed gout and hyperuricaemia were investigated and compared with the general population. Results: The prevalence of gout increased from 6.7 per 1000 inhabitants in 2005 to 9.1 per 1000 inhabitants in 2009. It increased with advancing age and was fourfold higher in men. A similar trend was observed for asymptomatic hyperuricaemia (85.4 per 1000 inhabitants in 2005 vs 119.3 per 1000 inhabitants in 2009). The incidence of gout remained stable during the observation years (0.93 per 1000 person years in 2005 vs 0.95 in 2009). Recurrent episode rate was 19.1% during the first year following the first gout attack and 31.6% during the following 5 years. Advanced age, increased levels of uric acid, nephrolithiasis and concomitant use of ciclosporin were the main predictors of recurrence of gout attacks. Conclusion: The prevalence of gout and hyperuricaemia increased in Italy from 2005 to 2009. A high recurrence rate for gout attack was observed during the first year following the first episode. Early management of hyperuricaemia in patients at higher risk of recurrent gout attack should be considered in primary care.

AB - Objective: To assess the epidemiology of gout and hyperuricaemia in the Italian general population during the years 2005-2009. Methods: Using the Italian primary care database (Health Search/CSD Longitudinal Patient Database), the prevalence, incidence and recurrence rates of gout and/ or hyperuricaemia (serum urate level >360 mmol/l (6 mg/dl)) in outpatients aged ≥18 years during the years 2005-2009 were estimated. Rates together with 95% CI were measured overall and stratified by age, gender and calendar year. The characteristics of patients with newly diagnosed gout and hyperuricaemia were investigated and compared with the general population. Results: The prevalence of gout increased from 6.7 per 1000 inhabitants in 2005 to 9.1 per 1000 inhabitants in 2009. It increased with advancing age and was fourfold higher in men. A similar trend was observed for asymptomatic hyperuricaemia (85.4 per 1000 inhabitants in 2005 vs 119.3 per 1000 inhabitants in 2009). The incidence of gout remained stable during the observation years (0.93 per 1000 person years in 2005 vs 0.95 in 2009). Recurrent episode rate was 19.1% during the first year following the first gout attack and 31.6% during the following 5 years. Advanced age, increased levels of uric acid, nephrolithiasis and concomitant use of ciclosporin were the main predictors of recurrence of gout attacks. Conclusion: The prevalence of gout and hyperuricaemia increased in Italy from 2005 to 2009. A high recurrence rate for gout attack was observed during the first year following the first episode. Early management of hyperuricaemia in patients at higher risk of recurrent gout attack should be considered in primary care.

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