Epidemiology of haemolytic uremic syndrome in children. Data from the North Italian HUS network

Gianluigi Ardissino, Stefania Salardi, Elisa Colombo, Sara Testa, Nicolò Borsa-Ghiringhelli, Fabio Paglialonga, Valentina Paracchini, Francesca Tel, Ilaria Possenti, Mirco Belingheri, Cristina Felice Civitillo, Stefano Sardini, Rossella Ceruti, Carlo Baldioli, Paola Tommasi, Luciana Parola, Fiorella Russo, Silvana Tedeschi

Research output: Contribution to journalArticlepeer-review


Despite the severity of HUS and the fact that it represents a leading cause of acute kidney injury in children, the general epidemiology of HUS is all but well documented. The present study provides updated, population-based, purely epidemiological information on HUS in childhood from a large and densely populated area of northern Italy (9.6 million inhabitants, 1.6 million children). We systematically reviewed the files concerning patients with STEC-HUS and atypical HUS (aHUS) over a 10-year observation period (January 2003–December 2012). We included all incident cases with a documented first episode of HUS before the age of 18 years. We identified 101 cases of HUS during the 10 years. The overall mean annual incidence was 6.3 cases/million children aged

Original languageEnglish
Pages (from-to)465-473
Number of pages9
JournalEuropean Journal of Pediatrics
Issue number4
Publication statusPublished - 2016


  • Acute kidney injury
  • Children
  • Epidemiology
  • Haemolytic uremic syndrome
  • Incidence

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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