Epidemiology of haemolytic uremic syndrome in children. Data from the North Italian HUS network

Gianluigi Ardissino, Stefania Salardi, Elisa Colombo, Sara Testa, Nicolò Borsa-Ghiringhelli, Fabio Paglialonga, Valentina Paracchini, Francesca Tel, Ilaria Possenti, Mirco Belingheri, Cristina Felice Civitillo, Stefano Sardini, Rossella Ceruti, Carlo Baldioli, Paola Tommasi, Luciana Parola, Fiorella Russo, Silvana Tedeschi

Research output: Contribution to journalArticle

Abstract

Despite the severity of HUS and the fact that it represents a leading cause of acute kidney injury in children, the general epidemiology of HUS is all but well documented. The present study provides updated, population-based, purely epidemiological information on HUS in childhood from a large and densely populated area of northern Italy (9.6 million inhabitants, 1.6 million children). We systematically reviewed the files concerning patients with STEC-HUS and atypical HUS (aHUS) over a 10-year observation period (January 2003–December 2012). We included all incident cases with a documented first episode of HUS before the age of 18 years. We identified 101 cases of HUS during the 10 years. The overall mean annual incidence was 6.3 cases/million children aged

Original languageEnglish
Pages (from-to)465-473
Number of pages9
JournalEuropean Journal of Pediatrics
Volume175
Issue number4
DOIs
Publication statusPublished - 2016

Keywords

  • Acute kidney injury
  • Children
  • Epidemiology
  • Haemolytic uremic syndrome
  • Incidence

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Ardissino, G., Salardi, S., Colombo, E., Testa, S., Borsa-Ghiringhelli, N., Paglialonga, F., Paracchini, V., Tel, F., Possenti, I., Belingheri, M., Civitillo, C. F., Sardini, S., Ceruti, R., Baldioli, C., Tommasi, P., Parola, L., Russo, F., & Tedeschi, S. (2016). Epidemiology of haemolytic uremic syndrome in children. Data from the North Italian HUS network. European Journal of Pediatrics, 175(4), 465-473. https://doi.org/10.1007/s00431-015-2642-1