Epidemiology of HEV in the mediterranean basin

10-year prevalence in Italy

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objectives: The present study is aimed at describing the seroprevalence and exploring potential risk factor (s) for hepatitis E virus (HEV) in participants who voluntarily underwent anti-HIV antibody testing. Study design: Seroprevalence study. Setting: The HIV prevention unit at the National Institute for Infectious Diseases Lazzaro Spallanzani, serving as a referral centre for HIV infection in Lazio, an Italian Region with about 5.6 million inhabitants. Participants: Participants are a random sample of all subjects who receive counselling and undergo serological tests for anti-HIV antibody (Ab) between 2002 and 2011. Risk factors and outcome: A set of 16 epidemiological variables (risk factors) were assessed for association with positivity to anti-HEV IgG (outcome). Results: Between 2002 and 2011, 27 351 serum specimens and related epidemiological information were collected; of these 1116 were randomly selected and analysed. The overall anti-HEV IgG prevalence was 5.38% ((60 out of 1116) with evidence of potential heterogeneity between years of sampling (p=0.055). Multivariate analysis provided evidence that anti-HEV IgG prevalence increases by 4% per year of participants' age (95% CI 1% to 7%, p=0.002). In addition, men who have sex with men and participants who were born outside Italy have an OR for past HEV infection that is about two times higher than in those who were not (p=0.040 and p=0.027, respectively). Analysis of temporal trend showed that variation of anti-HEV IgG can be well explained by a cubic logistic regression model, which describes the variation of prevalence over time as a fluctuation within a 3-year period (p=0.032). Conclusions: This study provides new evidence that besides the orofecal and zoonotic routes, intimate contacts between males may be a significant mode of HEV transmission.

Original languageEnglish
Article numbere007110
JournalBMJ Open
Volume5
Issue number7
DOIs
Publication statusPublished - 2015

Fingerprint

Hepatitis E virus
Italy
Epidemiology
Immunoglobulin G
HIV Antibodies
Seroepidemiologic Studies
Anti-Idiotypic Antibodies
Logistic Models
Zoonoses
Serologic Tests
Virus Diseases
HIV Infections
Communicable Diseases
Counseling
Referral and Consultation
Multivariate Analysis
HIV
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{012a7f0e166f4812851ed5444b8c906c,
title = "Epidemiology of HEV in the mediterranean basin: 10-year prevalence in Italy",
abstract = "Objectives: The present study is aimed at describing the seroprevalence and exploring potential risk factor (s) for hepatitis E virus (HEV) in participants who voluntarily underwent anti-HIV antibody testing. Study design: Seroprevalence study. Setting: The HIV prevention unit at the National Institute for Infectious Diseases Lazzaro Spallanzani, serving as a referral centre for HIV infection in Lazio, an Italian Region with about 5.6 million inhabitants. Participants: Participants are a random sample of all subjects who receive counselling and undergo serological tests for anti-HIV antibody (Ab) between 2002 and 2011. Risk factors and outcome: A set of 16 epidemiological variables (risk factors) were assessed for association with positivity to anti-HEV IgG (outcome). Results: Between 2002 and 2011, 27 351 serum specimens and related epidemiological information were collected; of these 1116 were randomly selected and analysed. The overall anti-HEV IgG prevalence was 5.38{\%} ((60 out of 1116) with evidence of potential heterogeneity between years of sampling (p=0.055). Multivariate analysis provided evidence that anti-HEV IgG prevalence increases by 4{\%} per year of participants' age (95{\%} CI 1{\%} to 7{\%}, p=0.002). In addition, men who have sex with men and participants who were born outside Italy have an OR for past HEV infection that is about two times higher than in those who were not (p=0.040 and p=0.027, respectively). Analysis of temporal trend showed that variation of anti-HEV IgG can be well explained by a cubic logistic regression model, which describes the variation of prevalence over time as a fluctuation within a 3-year period (p=0.032). Conclusions: This study provides new evidence that besides the orofecal and zoonotic routes, intimate contacts between males may be a significant mode of HEV transmission.",
author = "Simone Lanini and Garbuglia, {Anna Rosa} and Daniele Lapa and Vincenzo Puro and Assunta Navarra and Catia Pergola and Giuseppe Ippolito and Capobianchi, {Maria Rosaria}",
year = "2015",
doi = "10.1136/bmjopen-2014-007110",
language = "English",
volume = "5",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "7",

}

TY - JOUR

T1 - Epidemiology of HEV in the mediterranean basin

T2 - 10-year prevalence in Italy

AU - Lanini, Simone

AU - Garbuglia, Anna Rosa

AU - Lapa, Daniele

AU - Puro, Vincenzo

AU - Navarra, Assunta

AU - Pergola, Catia

AU - Ippolito, Giuseppe

AU - Capobianchi, Maria Rosaria

PY - 2015

Y1 - 2015

N2 - Objectives: The present study is aimed at describing the seroprevalence and exploring potential risk factor (s) for hepatitis E virus (HEV) in participants who voluntarily underwent anti-HIV antibody testing. Study design: Seroprevalence study. Setting: The HIV prevention unit at the National Institute for Infectious Diseases Lazzaro Spallanzani, serving as a referral centre for HIV infection in Lazio, an Italian Region with about 5.6 million inhabitants. Participants: Participants are a random sample of all subjects who receive counselling and undergo serological tests for anti-HIV antibody (Ab) between 2002 and 2011. Risk factors and outcome: A set of 16 epidemiological variables (risk factors) were assessed for association with positivity to anti-HEV IgG (outcome). Results: Between 2002 and 2011, 27 351 serum specimens and related epidemiological information were collected; of these 1116 were randomly selected and analysed. The overall anti-HEV IgG prevalence was 5.38% ((60 out of 1116) with evidence of potential heterogeneity between years of sampling (p=0.055). Multivariate analysis provided evidence that anti-HEV IgG prevalence increases by 4% per year of participants' age (95% CI 1% to 7%, p=0.002). In addition, men who have sex with men and participants who were born outside Italy have an OR for past HEV infection that is about two times higher than in those who were not (p=0.040 and p=0.027, respectively). Analysis of temporal trend showed that variation of anti-HEV IgG can be well explained by a cubic logistic regression model, which describes the variation of prevalence over time as a fluctuation within a 3-year period (p=0.032). Conclusions: This study provides new evidence that besides the orofecal and zoonotic routes, intimate contacts between males may be a significant mode of HEV transmission.

AB - Objectives: The present study is aimed at describing the seroprevalence and exploring potential risk factor (s) for hepatitis E virus (HEV) in participants who voluntarily underwent anti-HIV antibody testing. Study design: Seroprevalence study. Setting: The HIV prevention unit at the National Institute for Infectious Diseases Lazzaro Spallanzani, serving as a referral centre for HIV infection in Lazio, an Italian Region with about 5.6 million inhabitants. Participants: Participants are a random sample of all subjects who receive counselling and undergo serological tests for anti-HIV antibody (Ab) between 2002 and 2011. Risk factors and outcome: A set of 16 epidemiological variables (risk factors) were assessed for association with positivity to anti-HEV IgG (outcome). Results: Between 2002 and 2011, 27 351 serum specimens and related epidemiological information were collected; of these 1116 were randomly selected and analysed. The overall anti-HEV IgG prevalence was 5.38% ((60 out of 1116) with evidence of potential heterogeneity between years of sampling (p=0.055). Multivariate analysis provided evidence that anti-HEV IgG prevalence increases by 4% per year of participants' age (95% CI 1% to 7%, p=0.002). In addition, men who have sex with men and participants who were born outside Italy have an OR for past HEV infection that is about two times higher than in those who were not (p=0.040 and p=0.027, respectively). Analysis of temporal trend showed that variation of anti-HEV IgG can be well explained by a cubic logistic regression model, which describes the variation of prevalence over time as a fluctuation within a 3-year period (p=0.032). Conclusions: This study provides new evidence that besides the orofecal and zoonotic routes, intimate contacts between males may be a significant mode of HEV transmission.

UR - http://www.scopus.com/inward/record.url?scp=84937238940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937238940&partnerID=8YFLogxK

U2 - 10.1136/bmjopen-2014-007110

DO - 10.1136/bmjopen-2014-007110

M3 - Article

VL - 5

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 7

M1 - e007110

ER -