Epidemiology of inflammatory bowel disease in the Republic of San Marino: The “EPIMICI – San Marino” study

Anna Chiara Piscaglia, Loris Riccardo Lopetuso, Lucrezia Laterza, Viviana Gerardi, Elena Sacchini, Emanuele Leoncini, Stefania Boccia, Maria Loredana Stefanelli, Antonio Gasbarrini, Alessandro Armuzzi

Research output: Contribution to journalArticle

Abstract

Background: The burden of Crohn's disease (CD) and ulcerative colitis (UC) has never been estimated in the Republic of San Marino, the third smallest nation of the world. Aims: To assess the occurrence and clinical features of CD and UC in San Marino during the last 35 years. Methods: We retrospectively evaluated the prevalence, incidence, and main clinical aspects of CD and UC from 1980 to 2014, crossing data from various sources. Results: Prevalence rates (per 100,000) on December 31, were 241 for CD (263 in males and 220 in females) and 311 for UC (370 in males and 255 in females). The specific incidence of UC steadily increased from 4.6 (95% CI: 1.5–10.6) in 1980–1984 to 12.4 (95% CI: 7.6–19.1) in 2010–2014; CD incidence showed a higher proportional increase, from 1.8 (95% CI: 0.2–6.6) in 1980–1984 to 17.9 (95% CI: 12.0–25.7) in 2010–2014. The main clinical features of CD and UC (activity and location at diagnosis, extra-intestinal manifestations, disease progression overtime, therapies, and hospitalizations) were analyzed. Conclusions: This study provides the first epidemiological report on CD and UC in San Marino, showing specific traits and overall higher prevalence and incidence rates than previously reported in neighbor Areas.

Original languageEnglish
JournalDigestive and Liver Disease
DOIs
Publication statusAccepted/In press - Jan 1 2018

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San Marino
Ulcerative Colitis
Inflammatory Bowel Diseases
Crohn Disease
Epidemiology
Incidence
Intestinal Diseases
Information Storage and Retrieval
Developing Countries
Disease Progression
Hospitalization

Keywords

  • Crohn's disease
  • Incidence
  • Prevalence
  • Ulcerative colitis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Epidemiology of inflammatory bowel disease in the Republic of San Marino : The “EPIMICI – San Marino” study. / Piscaglia, Anna Chiara; Lopetuso, Loris Riccardo; Laterza, Lucrezia; Gerardi, Viviana; Sacchini, Elena; Leoncini, Emanuele; Boccia, Stefania; Stefanelli, Maria Loredana; Gasbarrini, Antonio; Armuzzi, Alessandro.

In: Digestive and Liver Disease, 01.01.2018.

Research output: Contribution to journalArticle

Piscaglia, Anna Chiara ; Lopetuso, Loris Riccardo ; Laterza, Lucrezia ; Gerardi, Viviana ; Sacchini, Elena ; Leoncini, Emanuele ; Boccia, Stefania ; Stefanelli, Maria Loredana ; Gasbarrini, Antonio ; Armuzzi, Alessandro. / Epidemiology of inflammatory bowel disease in the Republic of San Marino : The “EPIMICI – San Marino” study. In: Digestive and Liver Disease. 2018.
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abstract = "Background: The burden of Crohn's disease (CD) and ulcerative colitis (UC) has never been estimated in the Republic of San Marino, the third smallest nation of the world. Aims: To assess the occurrence and clinical features of CD and UC in San Marino during the last 35 years. Methods: We retrospectively evaluated the prevalence, incidence, and main clinical aspects of CD and UC from 1980 to 2014, crossing data from various sources. Results: Prevalence rates (per 100,000) on December 31, were 241 for CD (263 in males and 220 in females) and 311 for UC (370 in males and 255 in females). The specific incidence of UC steadily increased from 4.6 (95{\%} CI: 1.5–10.6) in 1980–1984 to 12.4 (95{\%} CI: 7.6–19.1) in 2010–2014; CD incidence showed a higher proportional increase, from 1.8 (95{\%} CI: 0.2–6.6) in 1980–1984 to 17.9 (95{\%} CI: 12.0–25.7) in 2010–2014. The main clinical features of CD and UC (activity and location at diagnosis, extra-intestinal manifestations, disease progression overtime, therapies, and hospitalizations) were analyzed. Conclusions: This study provides the first epidemiological report on CD and UC in San Marino, showing specific traits and overall higher prevalence and incidence rates than previously reported in neighbor Areas.",
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AU - Piscaglia, Anna Chiara

AU - Lopetuso, Loris Riccardo

AU - Laterza, Lucrezia

AU - Gerardi, Viviana

AU - Sacchini, Elena

AU - Leoncini, Emanuele

AU - Boccia, Stefania

AU - Stefanelli, Maria Loredana

AU - Gasbarrini, Antonio

AU - Armuzzi, Alessandro

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N2 - Background: The burden of Crohn's disease (CD) and ulcerative colitis (UC) has never been estimated in the Republic of San Marino, the third smallest nation of the world. Aims: To assess the occurrence and clinical features of CD and UC in San Marino during the last 35 years. Methods: We retrospectively evaluated the prevalence, incidence, and main clinical aspects of CD and UC from 1980 to 2014, crossing data from various sources. Results: Prevalence rates (per 100,000) on December 31, were 241 for CD (263 in males and 220 in females) and 311 for UC (370 in males and 255 in females). The specific incidence of UC steadily increased from 4.6 (95% CI: 1.5–10.6) in 1980–1984 to 12.4 (95% CI: 7.6–19.1) in 2010–2014; CD incidence showed a higher proportional increase, from 1.8 (95% CI: 0.2–6.6) in 1980–1984 to 17.9 (95% CI: 12.0–25.7) in 2010–2014. The main clinical features of CD and UC (activity and location at diagnosis, extra-intestinal manifestations, disease progression overtime, therapies, and hospitalizations) were analyzed. Conclusions: This study provides the first epidemiological report on CD and UC in San Marino, showing specific traits and overall higher prevalence and incidence rates than previously reported in neighbor Areas.

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