TY - JOUR
T1 - Epidemiology of pancreatic neuroendocrine neoplasms: a gender perspective
AU - On Behalf Of Nike Group
AU - Muscogiuri, Giovanna
AU - Altieri, Barbara
AU - Albertelli, Manuela
AU - Dotto, Andrea
AU - Modica, Roberta
AU - Barrea, Luigi
AU - Fanciulli, Giuseppe
AU - Feola, Tiziana
AU - Baldelli, Roberto
AU - Ruggeri, Rosaria Maddalena
AU - Gallo, Marco
AU - Guarnotta, Valentina
AU - Malandrino, Pasqualino
AU - Messina, Erika
AU - Venneri, Mary Anna
AU - Giannetta, Elisa
AU - Ferone, Diego
AU - Colao, Annamaria
AU - Faggiano, Antongiulio
AU - Bottiglieri, Filomena
AU - Campione, Severo
AU - de Cicco, Federica
AU - Dicitore, Alessandra
AU - Ferraù, Francesco
AU - Grillo, Federica
AU - Grossrubatscher, Erika
AU - Guadagno, Elia
AU - Isidori, Andrea M.
AU - Lania, Andrea
AU - Lenzi, Andrea
AU - Calzo, Fabio Lo
AU - Pes, Luca
AU - Pizza, Genoveffa
AU - Pofi, Riccardo
AU - Puliani, Giulia
AU - Rainone, Carmen
AU - Razzore, Paola
AU - Rizza, Laura
AU - Rubino, Manila
AU - Sbardella, Emilia
AU - Sesti, Franz
AU - Vitale, Giovanni
AU - Zatelli, Maria Chiara
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Purpose: Pancreatic neuroendocrine neoplasms (PNENs) are a group of clinically rare and heterogeneous tumors of the pancreas. Currently there are no studies investigating the gender difference in PNEN susceptibility. Thus, the purpose of this study was aimed at examining how gender shapes risk factors, clinicopathological features, and comorbidities in PNENs. Methods: The study design consisted of an Italian multicenter, retrospective study. The study included all consecutive patients with PNENs followed at the participating centers. Two hundred and twenty-nine patients (105 males,124 females, age 54 ± 0.98 years) with PNENs were enrolled at the participating centers. The clinicopathological features (age, gender, BMI, histology, tumor size, tumor grade, distant metastasis, hormonal function, and diagnostic circumstances), comorbidities (cardiovascular diseases (CVD), pancreatitis, type 2 diabetes (T2DM), and potential risk factors (smoking and drinking) were included in the analysis. Results: Females were slightly prevalent (54.15%). PNENs were diagnosed at younger age in females compared to males (p = 0.04). The prevalence of CVD was significantly higher in males than in females (p = 0.006). In the female group, the presence of T2DM was significantly associated with higher tumor grade (p = 0.04) and metastatic disease (p = 0.02). The proportion of smokers and alcohol drinkers was significantly higher in the male group (p < 0.001). No significant gender differences were detected regarding the other parameters included in the analysis. Conclusions: This study has identified gender differences of PNENs in terms of age at diagnosis, associated comorbidities, and potential risk factors. A gender-tailored approach could become a potential strategy to better understand the natural history of PNENs and improve the effectiveness of PNENs clinical management.
AB - Purpose: Pancreatic neuroendocrine neoplasms (PNENs) are a group of clinically rare and heterogeneous tumors of the pancreas. Currently there are no studies investigating the gender difference in PNEN susceptibility. Thus, the purpose of this study was aimed at examining how gender shapes risk factors, clinicopathological features, and comorbidities in PNENs. Methods: The study design consisted of an Italian multicenter, retrospective study. The study included all consecutive patients with PNENs followed at the participating centers. Two hundred and twenty-nine patients (105 males,124 females, age 54 ± 0.98 years) with PNENs were enrolled at the participating centers. The clinicopathological features (age, gender, BMI, histology, tumor size, tumor grade, distant metastasis, hormonal function, and diagnostic circumstances), comorbidities (cardiovascular diseases (CVD), pancreatitis, type 2 diabetes (T2DM), and potential risk factors (smoking and drinking) were included in the analysis. Results: Females were slightly prevalent (54.15%). PNENs were diagnosed at younger age in females compared to males (p = 0.04). The prevalence of CVD was significantly higher in males than in females (p = 0.006). In the female group, the presence of T2DM was significantly associated with higher tumor grade (p = 0.04) and metastatic disease (p = 0.02). The proportion of smokers and alcohol drinkers was significantly higher in the male group (p < 0.001). No significant gender differences were detected regarding the other parameters included in the analysis. Conclusions: This study has identified gender differences of PNENs in terms of age at diagnosis, associated comorbidities, and potential risk factors. A gender-tailored approach could become a potential strategy to better understand the natural history of PNENs and improve the effectiveness of PNENs clinical management.
KW - Cardiovascular diseases
KW - Epidemiology
KW - Gender
KW - Pancreatic neuroendocrine neoplasms
KW - Sex
KW - Type 2 diabetes
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U2 - 10.1007/s12020-020-02331-3
DO - 10.1007/s12020-020-02331-3
M3 - Article
C2 - 32468269
AN - SCOPUS:85085682821
VL - 69
SP - 441
EP - 450
JO - Endocrine
JF - Endocrine
SN - 1355-008X
IS - 2
ER -