Epidemiology of pertussis in italy: Disease trends over the last century

M. V. Gonfantini, E. Carloni, F. Gesualdo, E. Pandolf, E. Agricola, E. Rizzuto, S. Iannazzo, M. L. Ciof Degli Atti, A. Villani, A. E. Tozzi

Research output: Contribution to journalArticlepeer-review


We reviewed the epidemiology of pertussis in Italy over the last 125 years to identify disease trends and factors that could have influenced these trends. We described mortality rates (1888–2012), case fatality rates (1925–2012), cumulative incidence rates (1925– 2013) and age-specific incidence rates (1974–2013). We compared data from routine surveillance with data from a paediatric sentinel surveillance system to estimate under-notification. Pertussis mortality decreased from 42.5 per 100,000 population in 1890 to no reported pertussis-related death after 2002. Incidence decreased from 86.3 per 100,000 in 1927 to 1 per 100,000 after 2008. Vaccine coverage increased from 32.8% in 1993 to about 96% after 2006. As for under-notification, mean sentinel/routine surveillance incidence ratio increased with age (from 1.8 in

Original languageEnglish
Article number20921
JournalEuro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin
Issue number40
Publication statusPublished - Oct 9 2014

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Virology
  • Medicine(all)


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