Epidemiology of viral respiratory tract infections in an outpatient haematology facility

Małgorzata Mikulska, Valerio Del Bono, Nemo Gandolfo, Simone Dini, Alida Dominietto, Carmen Di Grazia, Stefania Bregante, Riccardo Varaldo, Andrea Orsi, Filippo Ansaldi, Andrea Bacigalupo, Claudio Viscoli

Research output: Contribution to journalArticle

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Abstract

Viral respiratory tract infections (VRTI) are an important cause of morbidity and mortality in haematology patients, particularly after haematopoietic stem cell transplantation (HSCT). The incidence, clinical presentation and outcome of symptomatic and asymptomatic VRTI in HSCT outpatient unit were prospectively evaluated during a single influenza season (January-March 2011). Pharyngeal swabs were performed at the first visit and if new symptoms were present. Molecular multiplex assay for 12 respiratory viruses was performed by the regional reference laboratory. Among 264 swabs from 193 outpatients, 58 (22 %) resulted positive for 61 viruses (influenza, n = 20; respiratory syncytial virus [RSV], n = 21; rhinovirus, n = 12; coronavirus, n = 4; adenovirus, n = 3; parainfluenza, n = 1). VRTI were detected more frequently in the presence of symptoms than in asymptomatic patients: 49 out of 162 (30 %) vs. 9 out of 102 (9 %), p <0.001. Influenza-like illness syndrome (ILI) was significantly associated with a VRTI if compared to other presentations (42 %), while the European Centre for Disease Prevention and Control definition was not (30 %). Positive predictive value (PPV) of ILI for influenza was 17 %. Influenza and RSV peak periods were contemporary. Influenza prophylaxis was given to 25 patients following exposure. Low rate of progression from upper to lower respiratory tract infection (approximately 5 % for influenza and RSV), no nosocomial epidemics and no VRTI-related deaths were observed. VRTI are very frequent in high-risk haematology outpatients, but symptoms are aspecific and PPV of ILI is low. Symptoms of influenza and RSV overlap. Thus, microbiological diagnosis and contact preventive measures are crucial. Rather than universal influenza prophylaxis, prompt diagnosis and treatment of only documented infections could be pursued.

Original languageEnglish
Pages (from-to)669-676
Number of pages8
JournalAnnals of Hematology
Volume93
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Hematology
Respiratory Tract Infections
Human Influenza
Epidemiology
Outpatients
Respiratory Syncytial Viruses
Hematopoietic Stem Cell Transplantation
Paramyxoviridae Infections
Rhinovirus
Coronavirus
Centers for Disease Control and Prevention (U.S.)
Orthomyxoviridae
Adenoviridae
Viruses
Morbidity
Mortality
Incidence

Keywords

  • HSCT
  • Influenza
  • Influenza-like illness
  • Parainfluenza
  • Rhinovirus
  • RSV

ASJC Scopus subject areas

  • Hematology

Cite this

Epidemiology of viral respiratory tract infections in an outpatient haematology facility. / Mikulska, Małgorzata; Del Bono, Valerio; Gandolfo, Nemo; Dini, Simone; Dominietto, Alida; Di Grazia, Carmen; Bregante, Stefania; Varaldo, Riccardo; Orsi, Andrea; Ansaldi, Filippo; Bacigalupo, Andrea; Viscoli, Claudio.

In: Annals of Hematology, Vol. 93, No. 4, 2014, p. 669-676.

Research output: Contribution to journalArticle

Mikulska, Małgorzata ; Del Bono, Valerio ; Gandolfo, Nemo ; Dini, Simone ; Dominietto, Alida ; Di Grazia, Carmen ; Bregante, Stefania ; Varaldo, Riccardo ; Orsi, Andrea ; Ansaldi, Filippo ; Bacigalupo, Andrea ; Viscoli, Claudio. / Epidemiology of viral respiratory tract infections in an outpatient haematology facility. In: Annals of Hematology. 2014 ; Vol. 93, No. 4. pp. 669-676.
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