Epidermal growth factor receptor (EGFR): Mutational and protein expression analysis in gastric cancer

Enzo Mammano, Claudio Belluco, Manuela Sciro, Roberto Mencarelli, Marco Agostini, Mauro Michelotto, Alberto Marchet, Donato Nitti

Research output: Contribution to journalArticle

Abstract

Background: Since specific epidermal growth factor receptor (EGFR) somatic mutations have been demonstrated to influence the response to anti-EGFR therapy in non-small cell lung cancer, EGFR gene mutational analysis of different types of neoplasm is under investigation. Patients and Methods: EGFR protein expression and gene mutations in exons 18, 19 and 21 were investigated in 49 gastric adenocarcinomas. Results: no specific EGFR gene mutations were detected, while EGFR positive staining was detected in 6% of the cases. Conclusion: Our findings indicate that in gastric adenocarcinoma, specific EGFR gene mutations are very rare or absent and the rate of EGFR protein expression is low.

Original languageEnglish
Pages (from-to)3547-3550
Number of pages4
JournalAnticancer Research
Volume26
Issue number5 A
Publication statusPublished - Sep 2006

Fingerprint

erbB-1 Genes
Epidermal Growth Factor Receptor
Stomach Neoplasms
Mutation
Stomach
Proteins
Adenocarcinoma
Non-Small Cell Lung Carcinoma
Exons
Staining and Labeling
Neoplasms

Keywords

  • EGFR mutation
  • Epidermal growth factor receptor (EGFR)
  • Gastric cancer
  • Immunohistochemistry

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mammano, E., Belluco, C., Sciro, M., Mencarelli, R., Agostini, M., Michelotto, M., ... Nitti, D. (2006). Epidermal growth factor receptor (EGFR): Mutational and protein expression analysis in gastric cancer. Anticancer Research, 26(5 A), 3547-3550.

Epidermal growth factor receptor (EGFR) : Mutational and protein expression analysis in gastric cancer. / Mammano, Enzo; Belluco, Claudio; Sciro, Manuela; Mencarelli, Roberto; Agostini, Marco; Michelotto, Mauro; Marchet, Alberto; Nitti, Donato.

In: Anticancer Research, Vol. 26, No. 5 A, 09.2006, p. 3547-3550.

Research output: Contribution to journalArticle

Mammano, E, Belluco, C, Sciro, M, Mencarelli, R, Agostini, M, Michelotto, M, Marchet, A & Nitti, D 2006, 'Epidermal growth factor receptor (EGFR): Mutational and protein expression analysis in gastric cancer', Anticancer Research, vol. 26, no. 5 A, pp. 3547-3550.
Mammano E, Belluco C, Sciro M, Mencarelli R, Agostini M, Michelotto M et al. Epidermal growth factor receptor (EGFR): Mutational and protein expression analysis in gastric cancer. Anticancer Research. 2006 Sep;26(5 A):3547-3550.
Mammano, Enzo ; Belluco, Claudio ; Sciro, Manuela ; Mencarelli, Roberto ; Agostini, Marco ; Michelotto, Mauro ; Marchet, Alberto ; Nitti, Donato. / Epidermal growth factor receptor (EGFR) : Mutational and protein expression analysis in gastric cancer. In: Anticancer Research. 2006 ; Vol. 26, No. 5 A. pp. 3547-3550.
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