Epidermal growth factor receptor (EGFR): Mutational and protein expression analysis in gastric cancer

Enzo Mammano, Claudio Belluco, Manuela Sciro, Roberto Mencarelli, Marco Agostini, Mauro Michelotto, Alberto Marchet, Donato Nitti

Research output: Contribution to journalArticle

Abstract

Background: Since specific epidermal growth factor receptor (EGFR) somatic mutations have been demonstrated to influence the response to anti-EGFR therapy in non-small cell lung cancer, EGFR gene mutational analysis of different types of neoplasm is under investigation. Patients and Methods: EGFR protein expression and gene mutations in exons 18, 19 and 21 were investigated in 49 gastric adenocarcinomas. Results: no specific EGFR gene mutations were detected, while EGFR positive staining was detected in 6% of the cases. Conclusion: Our findings indicate that in gastric adenocarcinoma, specific EGFR gene mutations are very rare or absent and the rate of EGFR protein expression is low.

Original languageEnglish
Pages (from-to)3547-3550
Number of pages4
JournalAnticancer Research
Volume26
Issue number5 A
Publication statusPublished - Sep 2006

Keywords

  • EGFR mutation
  • Epidermal growth factor receptor (EGFR)
  • Gastric cancer
  • Immunohistochemistry

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Mammano, E., Belluco, C., Sciro, M., Mencarelli, R., Agostini, M., Michelotto, M., Marchet, A., & Nitti, D. (2006). Epidermal growth factor receptor (EGFR): Mutational and protein expression analysis in gastric cancer. Anticancer Research, 26(5 A), 3547-3550.