Epidermal growth factor receptor (EGFR)

Mutational and protein expression analysis in gastric cancer

Enzo Mammano, Claudio Belluco, Manuela Sciro, Roberto Mencarelli, Marco Agostini, Mauro Michelotto, Alberto Marchet, Donato Nitti

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: Since specific epidermal growth factor receptor (EGFR) somatic mutations have been demonstrated to influence the response to anti-EGFR therapy in non-small cell lung cancer, EGFR gene mutational analysis of different types of neoplasm is under investigation. Patients and Methods: EGFR protein expression and gene mutations in exons 18, 19 and 21 were investigated in 49 gastric adenocarcinomas. Results: no specific EGFR gene mutations were detected, while EGFR positive staining was detected in 6% of the cases. Conclusion: Our findings indicate that in gastric adenocarcinoma, specific EGFR gene mutations are very rare or absent and the rate of EGFR protein expression is low.

Original languageEnglish
Pages (from-to)3547-3550
Number of pages4
JournalAnticancer Research
Volume26
Issue number5 A
Publication statusPublished - Sep 2006

Fingerprint

erbB-1 Genes
Epidermal Growth Factor Receptor
Stomach Neoplasms
Mutation
Stomach
Proteins
Adenocarcinoma
Non-Small Cell Lung Carcinoma
Exons
Staining and Labeling
Neoplasms

Keywords

  • EGFR mutation
  • Epidermal growth factor receptor (EGFR)
  • Gastric cancer
  • Immunohistochemistry

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mammano, E., Belluco, C., Sciro, M., Mencarelli, R., Agostini, M., Michelotto, M., ... Nitti, D. (2006). Epidermal growth factor receptor (EGFR): Mutational and protein expression analysis in gastric cancer. Anticancer Research, 26(5 A), 3547-3550.

Epidermal growth factor receptor (EGFR) : Mutational and protein expression analysis in gastric cancer. / Mammano, Enzo; Belluco, Claudio; Sciro, Manuela; Mencarelli, Roberto; Agostini, Marco; Michelotto, Mauro; Marchet, Alberto; Nitti, Donato.

In: Anticancer Research, Vol. 26, No. 5 A, 09.2006, p. 3547-3550.

Research output: Contribution to journalArticle

Mammano, E, Belluco, C, Sciro, M, Mencarelli, R, Agostini, M, Michelotto, M, Marchet, A & Nitti, D 2006, 'Epidermal growth factor receptor (EGFR): Mutational and protein expression analysis in gastric cancer', Anticancer Research, vol. 26, no. 5 A, pp. 3547-3550.
Mammano E, Belluco C, Sciro M, Mencarelli R, Agostini M, Michelotto M et al. Epidermal growth factor receptor (EGFR): Mutational and protein expression analysis in gastric cancer. Anticancer Research. 2006 Sep;26(5 A):3547-3550.
Mammano, Enzo ; Belluco, Claudio ; Sciro, Manuela ; Mencarelli, Roberto ; Agostini, Marco ; Michelotto, Mauro ; Marchet, Alberto ; Nitti, Donato. / Epidermal growth factor receptor (EGFR) : Mutational and protein expression analysis in gastric cancer. In: Anticancer Research. 2006 ; Vol. 26, No. 5 A. pp. 3547-3550.
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