Epidermal growth factor receptor in human brain tumors

A. Di Carlo, A. Mariano, P. E. Macchia, M. C. Moroni, L. Beguinot, Vincenzo Macchia

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The expression of epidermal growth factor receptor (EGF-R) was examined in 27 primary human brain tumors (7 glioblastomas, 10 astrocytomas, 5 oligodendrogliomas, 1 schwannoma, 1 ganglioneuroma, 1 medulloblastoma, 1 ependimoma, 1 histiocitic lymphoma), in 6 brain metastases from lung carcinomas and in 20 meningiomas. Peritumoral tissues histologically normal excised surgically along with a large tumor were used as control. All plasma membranes from brain tissues tested showed specific EGF binding. The EGF receptor is expressed at low levels in the control human brain and at very high levels in 60% of the total intracranial tumors studied. When the various histological types of tumors were analyzed, the higher percentage of positive tumors was found with the meningiomas (85%) and the glioblastomas (71%), while the lower percentage of positivity was found with the oligodendrogliomas (40%) and the astrocytomas (30%). A good correlation between binding and total amount of EGF-R protein detected by Western Blot was also observed.

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalJournal of Endocrinological Investigation
Volume15
Issue number1
DOIs
Publication statusPublished - 1992

Fingerprint

Epidermal Growth Factor Receptor
Brain Neoplasms
Oligodendroglioma
Astrocytoma
Meningioma
Glioblastoma
Neoplasms
Brain
Ganglioneuroma
Medulloblastoma
Neurilemmoma
Epidermal Growth Factor
Lymphoma
Western Blotting
Cell Membrane
Neoplasm Metastasis
Carcinoma
Lung
Membranes
Proteins

Keywords

  • brain tumors
  • EGF receptor

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Di Carlo, A., Mariano, A., Macchia, P. E., Moroni, M. C., Beguinot, L., & Macchia, V. (1992). Epidermal growth factor receptor in human brain tumors. Journal of Endocrinological Investigation, 15(1), 31-37. https://doi.org/10.1007/BF03348650

Epidermal growth factor receptor in human brain tumors. / Di Carlo, A.; Mariano, A.; Macchia, P. E.; Moroni, M. C.; Beguinot, L.; Macchia, Vincenzo.

In: Journal of Endocrinological Investigation, Vol. 15, No. 1, 1992, p. 31-37.

Research output: Contribution to journalArticle

Di Carlo, A, Mariano, A, Macchia, PE, Moroni, MC, Beguinot, L & Macchia, V 1992, 'Epidermal growth factor receptor in human brain tumors', Journal of Endocrinological Investigation, vol. 15, no. 1, pp. 31-37. https://doi.org/10.1007/BF03348650
Di Carlo, A. ; Mariano, A. ; Macchia, P. E. ; Moroni, M. C. ; Beguinot, L. ; Macchia, Vincenzo. / Epidermal growth factor receptor in human brain tumors. In: Journal of Endocrinological Investigation. 1992 ; Vol. 15, No. 1. pp. 31-37.
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