Epidermal growth factor receptor overexpression correlates with a poor prognosis in completely resected non-small-cell lung cancer

G. Selvaggi, S. Novello, V. Torri, E. Leonardo, P. De Giuli, P. Borasio, C. Mossetti, F. Ardissone, P. Lausi, G. V. Scagliotti

Research output: Contribution to journalArticle

Abstract

Background: We designed a prospective study to test epidermal growth factor receptor (EGFR) expression by immunohistochemistry (IHC) in resected stage I-IIIA non-small-cell lung cancer (NSCLC) and to correlate overexpression with survival. Patients and methods: EGFR expression was evaluated in 130 consecutive NSCLC patients after radical surgery (60 squamous cell carcinomas, 48 adenocarcinomas, 22 large cell carcinomas: stage I, 41 (31%); stage II, 37 (29%) and stage IIIA, 52 (40%). Results: Overall, 101 of 130 (78%) specimens expressed EGFR, and with a cut-off value of 10% positive cells 48 cases (37%) were classified as positive. At univariate analysis, EGFR was significantly more expressed in stage III (50%) than stage I (20%) and stage II (25%) (P

Original languageEnglish
Pages (from-to)28-32
Number of pages5
JournalAnnals of Oncology
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 2004

Keywords

  • Epidermal growth factor receptor
  • Non-small-cell lung cancer
  • Prognostic factors
  • Survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Selvaggi, G., Novello, S., Torri, V., Leonardo, E., De Giuli, P., Borasio, P., Mossetti, C., Ardissone, F., Lausi, P., & Scagliotti, G. V. (2004). Epidermal growth factor receptor overexpression correlates with a poor prognosis in completely resected non-small-cell lung cancer. Annals of Oncology, 15(1), 28-32. https://doi.org/10.1093/annonc/mdh011