Epidermal growth factor receptor overexpression correlates with a poor prognosis in completely resected non-small-cell lung cancer

G. Selvaggi, S. Novello, V. Torri, E. Leonardo, P. De Giuli, P. Borasio, C. Mossetti, F. Ardissone, P. Lausi, G. V. Scagliotti

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

Background: We designed a prospective study to test epidermal growth factor receptor (EGFR) expression by immunohistochemistry (IHC) in resected stage I-IIIA non-small-cell lung cancer (NSCLC) and to correlate overexpression with survival. Patients and methods: EGFR expression was evaluated in 130 consecutive NSCLC patients after radical surgery (60 squamous cell carcinomas, 48 adenocarcinomas, 22 large cell carcinomas: stage I, 41 (31%); stage II, 37 (29%) and stage IIIA, 52 (40%). Results: Overall, 101 of 130 (78%) specimens expressed EGFR, and with a cut-off value of 10% positive cells 48 cases (37%) were classified as positive. At univariate analysis, EGFR was significantly more expressed in stage III (50%) than stage I (20%) and stage II (25%) (P

Original languageEnglish
Pages (from-to)28-32
Number of pages5
JournalAnnals of Oncology
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 2004

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Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Large Cell Carcinoma
Squamous Cell Carcinoma
Adenocarcinoma
Immunohistochemistry
Prospective Studies
Survival

Keywords

  • Epidermal growth factor receptor
  • Non-small-cell lung cancer
  • Prognostic factors
  • Survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Epidermal growth factor receptor overexpression correlates with a poor prognosis in completely resected non-small-cell lung cancer. / Selvaggi, G.; Novello, S.; Torri, V.; Leonardo, E.; De Giuli, P.; Borasio, P.; Mossetti, C.; Ardissone, F.; Lausi, P.; Scagliotti, G. V.

In: Annals of Oncology, Vol. 15, No. 1, 01.2004, p. 28-32.

Research output: Contribution to journalArticle

Selvaggi, G, Novello, S, Torri, V, Leonardo, E, De Giuli, P, Borasio, P, Mossetti, C, Ardissone, F, Lausi, P & Scagliotti, GV 2004, 'Epidermal growth factor receptor overexpression correlates with a poor prognosis in completely resected non-small-cell lung cancer', Annals of Oncology, vol. 15, no. 1, pp. 28-32. https://doi.org/10.1093/annonc/mdh011
Selvaggi, G. ; Novello, S. ; Torri, V. ; Leonardo, E. ; De Giuli, P. ; Borasio, P. ; Mossetti, C. ; Ardissone, F. ; Lausi, P. ; Scagliotti, G. V. / Epidermal growth factor receptor overexpression correlates with a poor prognosis in completely resected non-small-cell lung cancer. In: Annals of Oncology. 2004 ; Vol. 15, No. 1. pp. 28-32.
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AU - Novello, S.

AU - Torri, V.

AU - Leonardo, E.

AU - De Giuli, P.

AU - Borasio, P.

AU - Mossetti, C.

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