TY - JOUR
T1 - Epidermal growth factor-related peptides as targets for experimental therapy of human colon carcinoma
AU - Normanno, N.
AU - De Luca, A.
AU - Salomon, D. S.
AU - Ciardiello, F.
PY - 1998
Y1 - 1998
N2 - Colorectal carcinomas generally show a poor sensitivity to conventional chemotherapeutics. Therefore, novel therapeutic approaches are required to improve the prognosis of colon cancer patients in advanced stage. Several growth factors are involved in the control of colon carcinoma cell proliferation. In particular, the epidermal growth factor (EGF)-related peptides transforming growth factor-α (TGF-α), amphiregulin (AR), and CRIPTO (CR) are frequently overexpressed in human colon carcinomas. It has also been recently demonstrated that they can function as autocrine growth factors in human colon carcinoma cells. In fact, antisense (AS) retroviral expression vectors or AS oligonucleotides directed against TGF-α, AR, or CR are able to inhibit growth and transformation of several human colon carcinoma cell lines. These data suggest that the EGF-like growth factors and their receptors offer potential as targets for experimental therapy of human colon carcinoma. This article reviews the most recent findings in this field.
AB - Colorectal carcinomas generally show a poor sensitivity to conventional chemotherapeutics. Therefore, novel therapeutic approaches are required to improve the prognosis of colon cancer patients in advanced stage. Several growth factors are involved in the control of colon carcinoma cell proliferation. In particular, the epidermal growth factor (EGF)-related peptides transforming growth factor-α (TGF-α), amphiregulin (AR), and CRIPTO (CR) are frequently overexpressed in human colon carcinomas. It has also been recently demonstrated that they can function as autocrine growth factors in human colon carcinoma cells. In fact, antisense (AS) retroviral expression vectors or AS oligonucleotides directed against TGF-α, AR, or CR are able to inhibit growth and transformation of several human colon carcinoma cell lines. These data suggest that the EGF-like growth factors and their receptors offer potential as targets for experimental therapy of human colon carcinoma. This article reviews the most recent findings in this field.
KW - Antisense oligonucleotides
KW - Colon cancer
KW - Growth factors
UR - http://www.scopus.com/inward/record.url?scp=0031930513&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031930513&partnerID=8YFLogxK
M3 - Article
C2 - 9466051
AN - SCOPUS:0031930513
VL - 22
SP - 62
EP - 67
JO - Cancer Detection and Prevention
JF - Cancer Detection and Prevention
SN - 0361-090X
IS - 1
ER -