Epidoxorubicin versus no treatment as consolidation therapy in advanced ovarian cancer: Results from a phase II study

G. Bolis, S. Danese, S. Tateo, E. Rabaiotti, G. D'Agostino, C. Merisio, G. Scarfone, G. Polverino, F. Parazzini

Research output: Contribution to journalArticle

Abstract

To compare the effect of epidoxorubicin given for 4 months versus no treatment in the survival of patients with advanced ovarian cancer and complete pathologic response after first-line surgery and chemotherapy with platinum-based schedules, we conducted a multicenter randomized clinical trial. Patients with histologic diagnosis of epithelial ovarian cancer FIGO stage III or IV at first diagnosis; complete pathologic response at second-look laparotomy/laparoscopy or complete clinic response; and those who have had first-line therapy including surgery and one regimen containing cisplatin or carboplatinum were eligible for the study and were randomly allocated to epidoxorubicin 120 mg/sqm or no treatment. A total of 64 women were allocated to epidoxorubicin and 74 to no treatment. There were 20 and 19 deaths, respectively, in the epidoxorubicin and no-treatment groups. The 3-year percent overall survival was 79.0% and 78.7%, respectively, in the no-treatment and epidoxorubicin groups (log-rank test, P = 0.93).

Original languageEnglish
Pages (from-to)74-78
Number of pages5
JournalInternational Journal of Gynecological Cancer
Volume16
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Feb 2006

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Keywords

  • Consolidation treatment
  • Epidoxorubicin
  • Ovarian cancer

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology
  • Cancer Research

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