Epigenetic alterations in human parathyroid tumors

Chiara Verdelli, Irene Forno, Valentina Vaira, Sabrina Corbetta

Research output: Contribution to journalArticle

Abstract

Epigenetics alterations are involved in tumorigenesis and have been identified in endocrine neoplasia. In particular, DNA methylation, microRNAs deregulations and histone methylation impairment are detected in tumors of the parathyroid glands. Parathyroid tumors are the second most common endocrine neoplasia following thyroid cancer in women, and it is associated with primary hyperparathyroidism, a disease sustained by PTH hypersecretion. Despite the hallmark of global promoter hypomethylations was not detectable in parathyroid tumors, increase of hypermethylation in specific CpG islands was detected in the progression from benign to malignant parathyroid tumors. Furthermore, deregulation of a panel of embryonic-related microRNAs (miRNAs) was documented in parathyroid tumors compared with normal glands. Impaired expression of the histone methyltransferases EZH2, BMI1, and RIZ1 have been described in parathyroid tumors. Moreover, histone methyltransferases have been shown to be modulated by the oncosuppressors HIC1, MEN1, and HRPT2/CDC73 gene products that characterize tumorigenesis of parathyroid adenomas and carcinomas, respectively. The epigenetic scenario in parathyroid tumors have just began to be decoded but emerging data highlight the involvement of an embryonic gene signature in parathyroid tumor development.

Original languageEnglish
Pages (from-to)324-332
Number of pages9
JournalEndocrine
Volume49
Issue number2
DOIs
Publication statusPublished - Feb 27 2015

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Epigenomics
Neoplasms
Parathyroid Neoplasms
MicroRNAs
Carcinogenesis
Multiple Endocrine Neoplasia Type 1
CpG Islands
Parathyroid Glands
Primary Hyperparathyroidism
DNA Methylation
Thyroid Neoplasms
Histones
Methylation
Genes

Keywords

  • DNA methylation
  • Histone
  • microRNAs signature
  • Parathyroid tumors

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Epigenetic alterations in human parathyroid tumors. / Verdelli, Chiara; Forno, Irene; Vaira, Valentina; Corbetta, Sabrina.

In: Endocrine, Vol. 49, No. 2, 27.02.2015, p. 324-332.

Research output: Contribution to journalArticle

Verdelli, Chiara ; Forno, Irene ; Vaira, Valentina ; Corbetta, Sabrina. / Epigenetic alterations in human parathyroid tumors. In: Endocrine. 2015 ; Vol. 49, No. 2. pp. 324-332.
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