Epigenetic alterations in muscular disorders

Chiara Lanzuolo

Research output: Contribution to journalArticlepeer-review

Abstract

Epigenetic mechanisms, acting via chromatin organization, fix in time and space different transcriptional programs and contribute to the quality, stability, and heritability of cell-specific transcription programs. In the last years, great advances have been made in our understanding of mechanisms by which this occurs in normal subjects. However, only a small part of the complete picture has been revealed. Abnormal gene expression patterns are often implicated in the development of different diseases, and thus epigenetic studies from patients promise to fill an important lack of knowledge, deciphering aberrant molecular mechanisms at the basis of pathogenesis and diseases progression. The identification of epigenetic modifications that could be used as targets for therapeutic interventions could be particularly timely in the light of pharmacologically reversion of pathological perturbations, avoiding changes in DNA sequences. Here I discuss the available information on epigenetic mechanisms that, altered in neuromuscular disorders, could contribute to the progression of the disease.

Original languageEnglish
Article number256892
JournalComparative and Functional Genomics
Volume2012
DOIs
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Biotechnology

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