Epigenetic basis of skeletal muscle regeneration

Pier Lorenzo Puri, Vittorio Sartorelli

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter focuses on the epigenetic regulation of muscle regeneration, as a paradigm for other tissues. Tissue and organ precursors are often referred to as adult "somatic stem cells" (SSCs) because of their functional analogies with the embryonic stem cells (ESCs), including the ability for long-term self-renewal and the potential to commit into multiple lineages. However, while ESCs are totipotent and can adopt virtually all lineages, SSCs are located within differentiated tissues and organs, have restricted "potency," and provide an immediate reservoir for repair upon injury or disease associated events. Lineage commitment, migration, proliferation, and differentiation of SSCs are regulated by the coordinated activation and repression of distinct subsets of genes in response to cues released within the regenerative environment. The extensive knowledge gained on muscle stem cells (MSCs) makes muscle regeneration an interesting paradigm to unveil general principles of epigenetic regulation of tissue regeneration and to investigate strategies for regenerative medicine using SSCs.

Original languageEnglish
Title of host publicationHandbook of Epigenetics
PublisherElsevier Inc.
Number of pages11
ISBN (Print)9780123757098
Publication statusPublished - 2011

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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