Epigenetic Changes Associated with the Expression of Amyotrophic Lateral Sclerosis (ALS) Causing Genes

Alessandra Masala, Simona Sanna, Sonia Esposito, Mauro Rassu, Manuela Galioto, Angelo Zinellu, Ciriaco Carru, Maria Teresa Carrì, Ciro Iaccarino, Claudia Crosio

Research output: Contribution to journalArticlepeer-review

Abstract

Neurodegenerative disorders, including Amyotrophic Lateral Sclerosis (ALS), have been associated to alterations in chromatin structure resulting in long-lasting changes in gene expression. ALS is predominantly a sporadic disease and environmental triggers may be involved in its onset. In this respect, alterations in the epigenome can provide the key to transform the genetic information into phenotype. In this paper, we demonstrate that two modifications associated with transcriptional activation, namely dimethylation of lysine 4 on H3 tail (H3K4me2) and phospho-acetylation of serine 10 and lysine 14 on H3 tail (H3K14ac-S10ph), and two modifications associated to transcriptional repression, namely trimethylation of lysine 9 on H3 tail (H3K9me3) and DNA methylation are selectively altered in cellular and animal model of ALS. These results reinforce the idea that epigenetic therapy may represent a potential and attractive approach for ALS treatment.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalNeuroscience
Volume390
DOIs
Publication statusPublished - Oct 15 2018

Keywords

  • Amyotrophic Lateral Sclerosis
  • DNA methylation
  • FUS
  • histone posttranslational modifications
  • SOD1
  • TDP43

ASJC Scopus subject areas

  • Neuroscience(all)

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